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anti-CYP3A43 antibody :: Rabbit anti-Human Cytochrome P450 3A43 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9605040
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 3A43 (CYP3A43), Polyclonal Antibody

★Popular Item★
 Also Known As   

Cytochrome P450 3A43 Antibody

 Product Synonym Names    Cytochrome P450 family 3 subfamily A polypeptide 43; Cytochrome P450 polypeptide 43; Cytochrome P450 subfamily IIIA polypeptide 43; MGC119315; MGC119316
 Product Gene Name   

anti-CYP3A43 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9HB55
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Cytochrome P450 3A43 antibody detects endogenous levels of total Cytochrome P450 3A43
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Endoplasmic Reticulum Membrane; Peripheral Membrane Protein. Microsome Membrane; Peripheral Membrane Protein.
 Tissue Specificity    Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-CYP3A43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYP3A43 antibody

   Function: Exhibits low testosterone 6-beta-hydroxylase activity.
Similarity: Belongs to the cytochrome P450 family.
 Applications Tested/Suitable for anti-CYP3A43 antibody   

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-CYP3A43 antibody    WB: 1:500-1:1000
IF/ICC: 1:100-1:500
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 Western Blot (WB) of anti-CYP3A43 antibody    Western blot analysis of extracts from Jurkat cells, using Cytochrome P450 3A43 antibody.The lane on the left is treated with the antigen-specific peptide.
anti-CYP3A43 antibody Western Blot (WB) (WB) image
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 Immunofluorescene (IF) of anti-CYP3A43 antibody    MBS9605040 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
anti-CYP3A43 antibody Immunofluorescene (IF) image
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NCBI/Uniprot data below describe general gene information for CYP3A43. It may not necessarily be applicable to this product.
 NCBI GI #    525458843
 NCBI GeneID    64816
 NCBI Accession #    NP_001265850.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278921.1 [Other Products]
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 UniProt Primary Accession #    Q9HB55 [Other Products]
 UniProt Secondary Accession #    Q495Y1; Q75MK2; Q75MK3; Q9HB52; Q9HB53; Q9HB54; Q9HB57 [Other Products]
 UniProt Related Accession #    Q9HB55 [Other Products]
 Molecular Weight    Observed: 57 kD
Predicted: 58 kDa
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 NCBI Official Full Name    cytochrome P450 3A43 isoform 4
 NCBI Official Synonym Full Names    cytochrome P450 family 3 subfamily A member 43
 NCBI Official Symbol    CYP3A43 [Similar Products]
 NCBI Protein Information    cytochrome P450 3A43
 UniProt Protein Name    Cytochrome P450 3A43
 Protein Family    Cytochrome
 UniProt Gene Name    CYP3A43 [Similar Products]
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 NCBI Summary for CYP3A43    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
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 UniProt Comments for CYP3A43    Exhibits low testosterone 6-beta-hydroxylase activity.MiscellaneousChimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).
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 Research Articles on CYP3A43    1. Mutations in CYP3A43 gene is associated with prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP3A43 antibodyPathways associated with anti-CYP3A43 antibody
 Reference Product  PubMed Publications
 UGT1A4 antibody  >1 publications with CYP3A43 and UGT1A4
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Miscellaneous Substrates Pathway antibodies  Miscellaneous Substrates Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Xenobiotics Pathway antibodies  Xenobiotics Pathway Diagram
 Cytochrome P450 Pathway antibodies  Cytochrome P450 Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
Diseases associated with anti-CYP3A43 antibodyOrgans/Tissues associated with anti-CYP3A43 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >9 publications with CYP3A43 and Prostatic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with CYP3A43 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with CYP3A43 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with CYP3A43 and Nervous System Diseases
 Hyperplasia Antibodies  >2 publications with CYP3A43 and Hyperplasia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with CYP3A43 and Drug-Related Side Effects and Adverse Reactions
 Liver Neoplasms Antibodies  >2 publications with CYP3A43 and Liver Neoplasms
 Hypertension Antibodies  >2 publications with CYP3A43 and Hypertension
 Breast Neoplasms Antibodies  >2 publications with CYP3A43 and Breast Neoplasms
 Drug-Induced Liver Injury Antibodies  >2 publications with CYP3A43 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with CYP3A43 and Brain
 Testis Antibodies  >2 publications with CYP3A43 and Testis
 Ovary Antibodies  >1 publications with CYP3A43 and Ovary
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