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anti-KRT8 antibody :: Guinea pig Cytokeratin 8,18 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS621174 anti-KRT8 antibody
Unit / Price
0.1 mL  /  $695 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokeratin 8,18 (KRT8), Polyclonal Antibody

★Popular Item★
 Also Known As   

Cytokeratin 8,18

 Product Synonym Names    Anti -Cytokeratin 8,18
 Product Gene Name   

anti-KRT8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (53290971..53343650, complement). Location: 12q13
 OMIM    148060
 3D Structure    ModBase 3D Structure for P05787
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Guinea pig
 Species Reactivity    Human, rat, mouse, Syrian hamster, Xenopus laevis, chicken.
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 Specificity    Recognizes bovine Cytokeratin 8,18 of simple type epithelium at ~52.5kD and 45.5kD respectively. Detected all adeno-Ca tested, undifferentiated CA, hepatocellular CA and cervix Ca tumors.
 Purity/Purification    Serum
 Form/Format    Supplied as a liquid, 0.09% sodium azide.
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 Immunogen    Cytokeratin 8/18 filaments, reconstituted from purified bovine cytokeratins 8 and 18.
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 Preparation and Storage    May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-KRT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT8 antibody

   Cytokeratins are a family of water-insoluble intermediate laments, composed of polypeptide chains found in the cytoskeleton of epithelial cells. Twenty different forms of human cytokeratins exist (Moll numbers 1-20) in both normal and malignant epithelial cell lines. Speci c combinations of cytokeratin peptides are associated with certain epithelial cells, and are therefore useful in the characterization of poorly differentiated carcinoma. Cytokeratins may also be clinically signi cant indicators in distinguishing carcinoma from malignant tumors of non-epithelial origin, such as lymphoma, sarcoma, and melanoma. Cytokeratin 8 and 18 staining has also been observed in renal cell carcinomas, hepatocellular carcinomas, cholangiocarcinomas, germ cell tumors and some neuroendocrine carcinomas, epithelioid sarcomas and non-epithelial tumors.
 Product Categories/Family for anti-KRT8 antibody    Antibodies; Abs to Cytokeratin
 Applications Tested/Suitable for anti-KRT8 antibody   

Suitable for use in ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Other applications have not been tested.

 Application Notes for anti-KRT8 antibody    Western Blot: 1:2000
Immunohistochemistry (Frozen): 1:100.
Immunohistochemistry (Paraffin): 1:50. Microwave treatment recommended.

Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for KRT8. It may not necessarily be applicable to this product.
 NCBI GI #    30313
 NCBI GeneID    3856
 NCBI Accession #    CAA31376.1 [Other Products]
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 UniProt Primary Accession #    P05787 [Other Products]
 UniProt Secondary Accession #    Q14099; Q14716; Q14717; Q53GJ0; Q6DHW5; Q6GMY0; Q6P4C7; Q96J60; A8K4H3; B0AZN5; F8VXB4 [Other Products]
 UniProt Related Accession #    P05787 [Other Products]
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 NCBI Official Full Name    cytokeratin 8 (279 AA)
 NCBI Official Synonym Full Names    keratin 8
 NCBI Official Symbol    KRT8 [Similar Products]
 NCBI Official Synonym Symbols   
K8; KO; CK8; CK-8; CYK8; K2C8; CARD2
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8
 UniProt Protein Name    Keratin, type II cytoskeletal 8
 UniProt Synonym Protein Names   
Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
 Protein Family    Keratin
 UniProt Gene Name    KRT8 [Similar Products]
 UniProt Synonym Gene Names    CYK8; CK-8; K8 [Similar Products]
 UniProt Entry Name    K2C8_HUMAN
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 NCBI Summary for KRT8    This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for KRT8    K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; costamere; nuclear matrix; keratin filament; cytoplasm; intermediate filament; intercellular junction; Z disc; nucleus; sarcolemma

Molecular Function: protein binding; protein complex binding; structural molecule activity

Biological Process: viral reproduction; tumor necrosis factor-mediated signaling pathway; response to other organism; sarcomere organization; response to hydrostatic pressure

Disease: Cirrhosis, Familial
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 Research Articles on KRT8    1. These results indicate the role of K8/18 in modulating invasion in breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KRT8 antibodyDiseases associated with anti-KRT8 antibody
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >58 publications with KRT8 and Neoplasms
 Liver Diseases Antibodies  >30 publications with KRT8 and Liver Diseases
 Adenocarcinoma Antibodies  >16 publications with KRT8 and Adenocarcinoma
 Breast Neoplasms Antibodies  >15 publications with KRT8 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >12 publications with KRT8 and Neoplasm Metastasis
 Liver Cirrhosis Antibodies  >9 publications with KRT8 and Liver Cirrhosis
 Fibrosis Antibodies  >9 publications with KRT8 and Fibrosis
 Liver Neoplasms Antibodies  >9 publications with KRT8 and Liver Neoplasms
 Necrosis Antibodies  >6 publications with KRT8 and Necrosis
 Drug-Induced Liver Injury Antibodies  >6 publications with KRT8 and Drug-Induced Liver Injury
Organs/Tissues associated with anti-KRT8 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >42 publications with KRT8 and Liver
 Embryonic Tissue Antibodies  >12 publications with KRT8 and Embryonic Tissue
 Kidney Antibodies  >8 publications with KRT8 and Kidney
 Lung Antibodies  >7 publications with KRT8 and Lung
 Lymph Node Antibodies  >6 publications with KRT8 and Lymph Node
 Eye Antibodies  >5 publications with KRT8 and Eye
 Intestine Antibodies  >5 publications with KRT8 and Intestine
 Pancreas Antibodies  >4 publications with KRT8 and Pancreas
 Prostate Antibodies  >4 publications with KRT8 and Prostate
 Stomach Antibodies  >3 publications with KRT8 and Stomach
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