NP_004741.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,302 Da
NCBI Official Full Name
cytokine receptor-like factor 1
NCBI Official Synonym Full Names
cytokine receptor like factor 1
NCBI Official Synonym Symbols
CLF; NR6; CISS; CISS1; CLF-1; zcytor5 [Similar Products]
NCBI Protein Information
cytokine receptor-like factor 1
UniProt Protein Name
Cytokine receptor-like factor 1
UniProt Synonym Protein Names
Cytokine-like factor 1; CLF-1; ZcytoR5
UniProt Synonym Gene Names
NCBI Summary for CRLF1
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
UniProt Comments for CRLF1
CRLF1: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. Defects in CRLF1 are the cause of cold-induced sweating syndrome type 1 (CISS1). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Defects in CRLF1 are the cause of Crisponi syndrome (CRISPS). Crisponi syndrome is a rare autosomal recessive disorder characterized by congenital muscular contractions of facial muscles, with trismus in response to stimuli, dysmorphic features, bilateral camptodactyly, major feeding and respiratory difficulties, and access of hyperthermia leading to death in the first months of life. Belongs to the type I cytokine receptor family. Type 3 subfamily.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: extracellular region; extracellular space
Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; cytokine binding; protein binding; protein heterodimerization activity; receptor activity
Biological Process: negative regulation of neuron apoptosis; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein
Disease: Cold-induced Sweating Syndrome 1
Research Articles on CRLF1
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Products associated with anti-CRLF1 antibody
Diseases associated with anti-CRLF1 antibody
Organs/Tissues associated with anti-CRLF1 antibody
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