Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PHGDH rightarrow Polyclonal PHGDH  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Nutlin-3a Inhibitor
 • ALDOC Antibody
 • SGK1 Antibody
 • TpP ELISA Kit
 • MDK Antibody
 • Humanin-like protein 6 (MTRNR2L6) ELISA Kit
 • Lithium Acetoacetate Reagent
 • CRP Antibody
 • CD279 Antibody
 • F-box protein 7 (FBXO7) Antibody
 • HIF-1beta Antibody
 • CD273 Antibody
 • RANK Recombinant Protein
 • Voltage-gated hydrogen channel 1 (Hvcn1) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PHGDH antibody :: Rabbit anti-Human D-3-phosphoglycerate dehydrogenase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000726
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

D-3-phosphoglycerate dehydrogenase (PHGDH), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human D-3-phosphoglycerate dehydrogenase polyclonal Antibody

 Product Synonym Names    D-3-phosphoglycerate dehydrogenase protein; 3-PGDH£¬PGDH3£¬PHGDH
 Product Gene Name   

anti-PHGDH antibody

[Similar Products]
 Product Synonym Gene Name    PHGDH [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    256520
 3D Structure    ModBase 3D Structure for O43175
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
Section Bar
 Immunogen    Recombinant human D-3-phosphoglycerate dehydrogenase protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16222
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PHGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-PHGDH antibody

   PHGDH or 3-phosphoglycerate dehydrogenase is an enzyme belonging to the D-isomer specific 2-hydroxyacid dehydrogenase family. It catalysis the reaction 3-phosphoglycerate + NAD+ = 3-phosphonooxypyruvate + NADH during L-serine biosynthesis. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation and seizures.
 Product Categories/Family for anti-PHGDH antibody    Metabolism
 Applications Tested/Suitable for anti-PHGDH antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PHGDH antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
Section Bar
 Western Blot (WB) of anti-PHGDH antibody    All lanes: D-3-phosphoglycerate dehydrogenase antibody at 2ug/ml
Lane 1: EC109whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 59 kDa
Observed band size: 59 kDa

anti-PHGDH antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-PHGDH antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS7000726 at dilution of 1:100
anti-PHGDH antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-PHGDH antibody    Immunofluorescent analysis of MCF-7 cells using MBS7000726 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PHGDH antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunofluorescence (IF) of anti-PHGDH antibody    Immunofluorescent analysis of PC3 cells using MBS7000726 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PHGDH antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PHGDH. It may not necessarily be applicable to this product.
 NCBI GI #    23308577
 NCBI GeneID    26227
 NCBI Accession #    NP_006614.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006623.3 [Other Products]
Section Bar
 UniProt Primary Accession #    O43175 [Other Products]
 UniProt Secondary Accession #    Q5SZU3; Q9BQ01; B2RD08 [Other Products]
 UniProt Related Accession #    O43175 [Other Products]
 Molecular Weight    56,651 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    D-3-phosphoglycerate dehydrogenase
 NCBI Official Synonym Full Names    phosphoglycerate dehydrogenase
 NCBI Official Symbol    PHGDH [Similar Products]
 NCBI Official Synonym Symbols   
NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113
[Similar Products]
 NCBI Protein Information    D-3-phosphoglycerate dehydrogenase
 UniProt Protein Name    D-3-phosphoglycerate dehydrogenase
 Protein Family    D-3-phosphoglycerate dehydrogenase
 UniProt Gene Name    PHGDH [Similar Products]
 UniProt Synonym Gene Names    PGDH3; 3-PGDH [Similar Products]
 UniProt Entry Name    SERA_HUMAN
Section Bar
 NCBI Summary for PHGDH    This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
Section Bar
 UniProt Comments for PHGDH    PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Protein type: Oxidoreductase; Cell development/differentiation; EC 1.1.1.95; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 1p12

Cellular Component: cytosol; myelin sheath

Molecular Function: electron carrier activity; NAD binding; phosphoglycerate dehydrogenase activity

Biological Process: amino acid biosynthetic process; brain development; gamma-aminobutyric acid metabolic process; glial cell development; glutamine metabolic process; glycine metabolic process; L-serine biosynthetic process; neural tube development; neurite development; regulation of gene expression; serine family amino acid biosynthetic process; spinal cord development; taurine metabolic process; threonine metabolic process

Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency
Table BarTOPTable Bar
 Research Articles on PHGDH    1. p53-mediated repression of PHGDH enhances the apoptotic response upon serine starvation in melanoma cells.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PHGDH antibodyPathways associated with anti-PHGDH antibody
 Reference Product  PubMed Publications
 PSAT1 antibody  >13 publications with PHGDH and PSAT1
 Products by Pathway  Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
Diseases associated with anti-PHGDH antibodyOrgans/Tissues associated with anti-PHGDH antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >17 publications with PHGDH and Breast Neoplasms
 Nervous System Diseases Antibodies  >8 publications with PHGDH and Nervous System Diseases
 Melanoma Antibodies  >7 publications with PHGDH and Melanoma
 Brain Diseases Antibodies  >6 publications with PHGDH and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with PHGDH and Cell Transformation, Neoplastic
 Phosphoglycerate Dehydrogenase Deficiency Antibodies  >4 publications with PHGDH and Phosphoglycerate Dehydrogenase Deficiency
 Disease Models, Animal Antibodies  >4 publications with PHGDH and Disease Models, Animal
 Lung Neoplasms Antibodies  >3 publications with PHGDH and Lung Neoplasms
 Liver Diseases Antibodies  >3 publications with PHGDH and Liver Diseases
 Neoplasms, Experimental Antibodies  >3 publications with PHGDH and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with PHGDH and Brain
 Liver Antibodies  >9 publications with PHGDH and Liver
 Blood Antibodies  >9 publications with PHGDH and Blood
 Lung Antibodies  >6 publications with PHGDH and Lung
 Bone Antibodies  >3 publications with PHGDH and Bone
 Embryonic Tissue Antibodies  >3 publications with PHGDH and Embryonic Tissue
 Uterus Antibodies  >2 publications with PHGDH and Uterus
 Nerve Antibodies  >2 publications with PHGDH and Nerve
 Mammary Gland Antibodies  >1 publications with PHGDH and Mammary Gland
 Muscle Antibodies  >1 publications with PHGDH and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions