P21917.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
D(4) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D4
NCBI Official Synonym Symbols
NCBI Protein Information
D(4) dopamine receptor; D(4) dopamine receptor; OTTHUMP00000164435; dopamine D4 receptor; D(2C) dopamine receptor; seven transmembrane helix receptor
UniProt Protein Name
D(4) dopamine receptor
UniProt Synonym Protein Names
D(2C) dopamine receptor; Dopamine D4 receptor
UniProt Entry Name
DRD4_HUMAN
NCBI Summary for DRD4
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq]
UniProt Comments for DRD4
Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subunit structure: Interacts with CLIC6
By similarity and GPRASP1. Ref.9
Subcellular location: Cell membrane; Multi-pass membrane protein.
Polymorphism: The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAL58637.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on DRD4
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Products associated with anti-DRD4 antibody
Pathways associated with anti-DRD4 antibody
Diseases associated with anti-DRD4 antibody
Organs/Tissues associated with anti-DRD4 antibody
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