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anti-D5DR antibody :: Rabbit D5DR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301190
Immunohistochemistry (IHC)
Unit / Price
0.1 mL (Concentrate)  /  $180 +1 FREE 8GB USB
7 mL (RTU)  /  $285 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $335 +1 FREE 8GB USB
1 mL (Concentrate)  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

D5DR, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Anti-Human D5DR Polyclonal Antibody

 Product Gene Name   

anti-D5DR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126453
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Chicken, Dog, Pig, Rabbit
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide corresponding to aa 459-477 of human D5DR.
 Control Tissue    Brain
 Cellular Localization    Cytoplasm, Membrane
 Entrez Gene Code    1816
 Pathway    Neuroscience
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-D5DR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-D5DR antibody

   The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics. D1DR and D5DR compose the D1 class of dopamine receptors, and D2DR, D3DR and D4DR compose the D2 class. D1 receptors stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity.
 Applications Tested/Suitable for anti-D5DR antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-D5DR antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:50
IHC Positive Control: Brain
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 Immunohistochemistry (IHC) of anti-D5DR antibody    Human brain stained with anti-D5DR antibody
anti-D5DR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for D5DR. It may not necessarily be applicable to this product.
 NCBI GI #    4503391
 NCBI GeneID    1816
 NCBI Accession #    NP_000789.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000798.4 [Other Products]
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 UniProt Secondary Accession #    Q8NEQ8; B2R9S3 [Other Products]
 UniProt Related Accession #    P21918 [Other Products]
 Molecular Weight    53 kDa
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 NCBI Official Full Name    D(1B) dopamine receptor
 NCBI Official Synonym Full Names    dopamine receptor D5
 NCBI Official Symbol    DRD5 [Similar Products]
 NCBI Official Synonym Symbols   
DBDR; DRD1B; DRD1L2
[Similar Products]
 NCBI Protein Information    D(1B) dopamine receptor; D(1B) dopamine receptor; D1beta dopamine receptor; d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor D1B
 UniProt Protein Name    D(1B) dopamine receptor
 UniProt Synonym Protein Names   
D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor
 UniProt Gene Name    DRD5 [Similar Products]
 UniProt Synonym Gene Names    DRD1B; DRD1L2 [Similar Products]
 UniProt Entry Name    DRD5_HUMAN
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 NCBI Summary for D5DR    This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for D5DR    DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: brush border membrane; integral to plasma membrane; plasma membrane

Molecular Function: dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; wound healing; response to amphetamine; adenylate cyclase activation; transmission of nerve impulse; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; response to cocaine; G-protein signaling, adenylate cyclase activating pathway; cellular calcium ion homeostasis; synaptic transmission; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; sensitization; negative regulation of blood pressure; positive regulation of adenylate cyclase activity; dopamine receptor, phospholipase C activating pathway; negative regulation of NAD(P)H oxidase activity; associative learning; dopamine receptor, adenylate cyclase activating pathway

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential
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 Research Articles on D5DR    1. This study demonistrated that Lymphocyte DR D5 is reduced in MS and IFN-beta restores their expression and responsiveness.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-D5DR antibodyPathways associated with anti-D5DR antibody
 Reference Product  PubMed Publications
 DRD1 antibody  >39 publications with D5DR and DRD1
 ADORA2A antibody  >2 publications with D5DR and ADORA2A
 ADORA2B antibody  >1 publications with D5DR and ADORA2B
 CRHR2 antibody  >1 publications with D5DR and CRHR2
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
Diseases associated with anti-D5DR antibodyOrgans/Tissues associated with anti-D5DR antibody
 Disease Name  Pubmed Publications
 Attention Deficit Disorder with Hyperactivity Antibodies  >65 publications with D5DR and Attention Deficit Disorder with Hyperactivity
 Nervous System Diseases Antibodies  >40 publications with D5DR and Nervous System Diseases
 Bipolar Disorder Antibodies  >11 publications with D5DR and Bipolar Disorder
 Hypertension Antibodies  >9 publications with D5DR and Hypertension
 Psychotic Disorders Antibodies  >7 publications with D5DR and Psychotic Disorders
 Parkinsonian Disorders Antibodies  >6 publications with D5DR and Parkinsonian Disorders
 Memory Disorders Antibodies  >5 publications with D5DR and Memory Disorders
 Cardiovascular Diseases Antibodies  >4 publications with D5DR and Cardiovascular Diseases
 Seizures Antibodies  >3 publications with D5DR and Seizures
 Blepharospasm Antibodies  >3 publications with D5DR and Blepharospasm
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >104 publications with D5DR and Brain
 Eye Antibodies  >4 publications with D5DR and Eye
 Ovary Antibodies  >2 publications with D5DR and Ovary
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