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anti-DAB2 antibody :: Rabbit DAB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS768460
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAB2, Polyclonal Antibody

★Popular Item★
 Also Known As   

DAB2 Rabbit Polyclonal

 Product Synonym Names    DAB2, Disabled homolog 2, DOC 2, DOC2, FLJ26626
 Product Gene Name   

anti-DAB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601236
 3D Structure    ModBase 3D Structure for P98082
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Human, Mouse ,Rat; other species are not tested. Please decide the specificity by homology
 Purity/Purification    Purification: Immunogen affinity purified
Purity: > or =95% as determined by SDS-PAGE
 Form/Format    Liquid
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 Immunogen    Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
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 Preparation and Storage    Store at -20 degree C for 24 months (Avoid repeated freeze/thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DAB2 antibody

   Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR.
 Applications Tested/Suitable for anti-DAB2 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

 Application Notes for anti-DAB2 antibody    WB : 1:500-1:5000
IP : 1:1000-1:10000
IF : 1:20-1:200
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 Immunofluorescent of anti-DAB2 antibody    Immunofluorescent analysis of HepG2 cells, using DAB2 antibody MBS768460 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
anti-DAB2 antibody Immunofluorescent image
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 SDS-PAGE of anti-DAB2 antibody    HeLa cells were subjected to SDS PAGE followed by western blot with MBS768460 (DAB2 antibody) at dilution of 1:1000
anti-DAB2 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for DAB2. It may not necessarily be applicable to this product.
 NCBI GI #    349585060
 NCBI GeneID    1601
 NCBI Accession #    NP_001231800.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001244871.1 [Other Products]
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 UniProt Primary Accession #    P98082 [Other Products]
 UniProt Secondary Accession #    Q13598; Q9BTY0; Q9UK04; A6NES5 [Other Products]
 UniProt Related Accession #    P98082 [Other Products]
 Molecular Weight    96 kDa
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 NCBI Official Full Name    disabled homolog 2 isoform 2
 NCBI Official Synonym Full Names    DAB2, clathrin adaptor protein
 NCBI Official Symbol    DAB2 [Similar Products]
 NCBI Official Synonym Symbols   
DOC2; DOC-2
[Similar Products]
 NCBI Protein Information    disabled homolog 2
 UniProt Protein Name    Disabled homolog 2
 UniProt Synonym Protein Names   
Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; DOC-2; Differentially-expressed protein 2
 Protein Family    Disabled
 UniProt Gene Name    DAB2 [Similar Products]
 UniProt Synonym Gene Names    DOC2; DOC-2 [Similar Products]
 UniProt Entry Name    DAB2_HUMAN
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 NCBI Summary for DAB2    This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for DAB2    DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.

Protein type: Tumor suppressor; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: clathrin coated vesicle membrane; clathrin-coated vesicle; coated pit; focal adhesion; intracellular membrane-bound organelle; lysosomal membrane; nucleolus; plasma membrane

Molecular Function: protein binding; protein C-terminus binding; SMAD binding

Biological Process: apoptosis; cell proliferation; integrin-mediated signaling pathway; leading edge cell differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; positive regulation of endocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein transport; receptor-mediated endocytosis; Wnt receptor signaling pathway
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 Research Articles on DAB2    1. DAB2 regulated the cell migration associated genes in PC3 cells, and the differential DAB2 expression between LNCaP and PC3 cells was partly regulated by histone 4 acetylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DAB2 antibodyPathways associated with anti-DAB2 antibody
 Reference Product  PubMed Publications
 LDLRAP1 antibody  >9 publications with DAB2 and LDLRAP1
 GRB2 antibody  >9 publications with DAB2 and GRB2
 LDLR antibody  >7 publications with DAB2 and LDLR
 SMAD2 antibody  >6 publications with DAB2 and SMAD2
 SMAD3 antibody  >5 publications with DAB2 and SMAD3
 MYO6 antibody  >2 publications with DAB2 and MYO6
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Formation Of Annular Gap Junctions Pathway antibodies  Formation Of Annular Gap Junctions Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
Diseases associated with anti-DAB2 antibodyOrgans/Tissues associated with anti-DAB2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >59 publications with DAB2 and Carcinoma
 Ovarian Neoplasms Antibodies  >28 publications with DAB2 and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >17 publications with DAB2 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >17 publications with DAB2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >17 publications with DAB2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >13 publications with DAB2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >12 publications with DAB2 and Nervous System Diseases
 Kidney Diseases Antibodies  >11 publications with DAB2 and Kidney Diseases
 Lung Neoplasms Antibodies  >10 publications with DAB2 and Lung Neoplasms
 Lung Diseases Antibodies  >10 publications with DAB2 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >33 publications with DAB2 and Kidney
 Prostate Antibodies  >26 publications with DAB2 and Prostate
 Blood Antibodies  >26 publications with DAB2 and Blood
 Brain Antibodies  >19 publications with DAB2 and Brain
 Embryonic Tissue Antibodies  >18 publications with DAB2 and Embryonic Tissue
 Vascular Antibodies  >18 publications with DAB2 and Vascular
 Lung Antibodies  >15 publications with DAB2 and Lung
 Nerve Antibodies  >14 publications with DAB2 and Nerve
 Liver Antibodies  >12 publications with DAB2 and Liver
 Muscle Antibodies  >10 publications with DAB2 and Muscle
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