NP_001335.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,497 Da
NCBI Official Full Name
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
NCBI Official Synonym Full Names
defender against cell death 1
NCBI Official Synonym Symbols
NCBI Protein Information
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; DAD-1; oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase 2 homolog; oligosaccharyltransferase subunit 2 (non-catalytic)
UniProt Protein Name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
UniProt Synonym Protein Names
Defender against cell death 1; DAD-1
UniProt Synonym Gene Names
UniProt Entry Name
DAD1_HUMAN
NCBI Summary for DAD1
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
UniProt Comments for DAD1
DAD1: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis. Belongs to the DAD/OST2 family.
Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Transferase; EC 2.4.99.18; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: endoplasmic reticulum membrane; membrane; oligosaccharyl transferase complex; integral to membrane
Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; oligosaccharyl transferase activity
Biological Process: response to drug; blastocyst development; cellular protein metabolic process; apoptosis; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; response to nutrient; negative regulation of apoptosis
Research Articles on DAD1
Precautions
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Products associated with anti-DAD1 antibody
Pathways associated with anti-DAD1 antibody
Diseases associated with anti-DAD1 antibody
Organs/Tissues associated with anti-DAD1 antibody
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