NP_004384.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,441 Da
NCBI Official Full Name
dystroglycan preproprotein
NCBI Official Synonym Full Names
dystroglycan 1
NCBI Official Synonym Symbols
A3a; DAG; AGRNR; 156DAG; MDDGA9; MDDGC7; MDDGC9 [Similar Products]
NCBI Protein Information
dystroglycan
UniProt Protein Name
Dystroglycan
UniProt Synonym Protein Names
Dystrophin-associated glycoprotein 1
UniProt Synonym Gene Names
UniProt Entry Name
DAG1_HUMAN
NCBI Summary for DAG1
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
UniProt Comments for DAG1
DAG1: a cytoskeletal protein that functions as a laminin receptor. Provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. May be involved in autosomal recessive muscular dystrophies. Its dramatic reduction in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. Binds to several types of arenaviruses. Is a target for the entry of Mycobacterium leprae into peripheral nerve Schwann cells. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 3p21
Cellular Component: basement membrane; basolateral plasma membrane; cell-cell adherens junction; costamere; cytoplasm; cytoskeleton; cytosol; dystroglycan complex; dystrophin-associated glycoprotein complex; extracellular region; extracellular space; filopodium; focal adhesion; integral to membrane; lamellipodium; lipid raft; nucleoplasm; plasma membrane; postsynaptic membrane; sarcolemma
Molecular Function: actin binding; alpha-actinin binding; calcium ion binding; laminin-1 binding; protein binding; protein complex binding; SH2 domain binding; structural constituent of muscle; tubulin binding; vinculin binding; viral receptor activity
Biological Process: calcium-dependent cell-matrix adhesion; cytoskeletal anchoring; entry of virus into host cell; extracellular matrix organization and biogenesis; membrane protein ectodomain proteolysis; morphogenesis of an epithelial sheet; myelination in the peripheral nervous system; negative regulation of cell migration; negative regulation of MAPKKK cascade; negative regulation of protein kinase B signaling cascade; nerve maturation; NLS-bearing substrate import into nucleus; protein amino acid O-linked glycosylation; regulation of gastrulation; response to peptide hormone stimulus; shape changes of embryonic cells; virus-host interaction
Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 9; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 9
Research Articles on DAG1
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Products associated with anti-DAG1 antibody
Pathways associated with anti-DAG1 antibody
Diseases associated with anti-DAG1 antibody
Organs/Tissues associated with anti-DAG1 antibody
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