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anti-DAGLA antibody :: Goat DAGLA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422238
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAGLA, Polyclonal Antibody

 Also Known As   

Goat anti-DAGLA Antibody

 Product Synonym Names    DAGLA; diacylglycerol lipase, alpha; C11orf11; DAGL(ALPHA); DAGLALPHA; NSDDR; diacylglycerol lipase alpha; neural stem cell-derived dendrite regulator; KIAA0659; DAGLA antibody; diacylglycerol lipase; alpha antibody; C11orf11 antibody; DAGL(ALPHA) antibody; DAGLALPHA antibody; NSDDR antibody; diacylglycerol lipase alpha antibody; neural stem cell-derived dendrite regulator antibody; KIAA0659 antibody
 Product Gene Name   

anti-DAGLA antibody

[Similar Products]
 Antibody/Peptide Pairs    DAGLA peptide (MBS425803) is used for blocking the activity of DAGLA antibody (MBS422238)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PAKQDELVIS AR
 OMIM    608687
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PAKQDELVISAR, from the C Terminus of the protein sequence according to NP_006124.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DAGLA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DAGLA antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-DAGLA antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
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 Western Blot (WB) of anti-DAGLA antibody    (0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DAGLA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DAGLA. It may not necessarily be applicable to this product.
 NCBI GI #    27262632
 NCBI GeneID    747
 NCBI Accession #    NP_006124.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006133.2 [Other Products]
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 UniProt Secondary Accession #    Q6WQJ0; A7E233 [Other Products]
 UniProt Related Accession #    Q9Y4D2 [Other Products]
 Molecular Weight    114,952 Da
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 NCBI Official Full Name    sn1-specific diacylglycerol lipase alpha
 NCBI Official Synonym Full Names    diacylglycerol lipase alpha
 NCBI Official Symbol    DAGLA [Similar Products]
 NCBI Official Synonym Symbols   
NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)
[Similar Products]
 NCBI Protein Information    sn1-specific diacylglycerol lipase alpha
 UniProt Protein Name    Sn1-specific diacylglycerol lipase alpha
 UniProt Synonym Protein Names   
Neural stem cell-derived dendrite regulator
 Protein Family    Sn1-specific diacylglycerol lipase
 UniProt Gene Name    DAGLA [Similar Products]
 UniProt Synonym Gene Names    C11orf11; KIAA0659; NSDDR; DGL-alpha [Similar Products]
 UniProt Entry Name    DGLA_HUMAN
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 NCBI Summary for DAGLA    This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
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 UniProt Comments for DAGLA    NSDDR: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Defects in DAGLA may be a cause of spinocerebellar ataxia type 20 (SCA20). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult- onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: acylglycerol lipase activity; metal ion binding

Biological Process: arachidonic acid metabolic process; diacylglycerol catabolic process; neuroblast proliferation; neurotransmitter biosynthetic process
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 Research Articles on DAGLA    1. In subcutaneous adipose tissue, DAGL-a mRNA was upregulated and fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mRNAs were down-regulated in obese subjects, but the diets had no influence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DAGLA antibodyDiseases associated with anti-DAGLA antibody
 Products by Pathway  Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Arachidonate Production From DAG Pathway antibodies  Arachidonate Production From DAG Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with DAGLA and Inflammation
 Atherosclerosis Antibodies  >1 publications with DAGLA and Atherosclerosis
 Fever Antibodies  >1 publications with DAGLA and Fever
 Brain Diseases Antibodies  >1 publications with DAGLA and Brain Diseases
 Disease Models, Animal Antibodies  >1 publications with DAGLA and Disease Models, Animal
Organs/Tissues associated with anti-DAGLA antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with DAGLA and Brain
 Bone Antibodies  >1 publications with DAGLA and Bone
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