NP_006124.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
sn1-specific diacylglycerol lipase alpha
NCBI Official Synonym Full Names
diacylglycerol lipase, alpha
NCBI Official Synonym Symbols
NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA) [Similar Products]
NCBI Protein Information
sn1-specific diacylglycerol lipase alpha
UniProt Protein Name
Sn1-specific diacylglycerol lipase alpha
UniProt Synonym Protein Names
Neural stem cell-derived dendrite regulator
UniProt Synonym Gene Names
UniProt Entry Name
DGLA_HUMAN
NCBI Summary for DAGLA
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
UniProt Comments for DAGLA
NSDDR: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Defects in DAGLA may be a cause of spinocerebellar ataxia type 20 (SCA20). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult- onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA. Belongs to the AB hydrolase superfamily. Lipase family.
Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; EC 3.1.1.-
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: metal ion binding; lipase activity
Biological Process: platelet activation; neuroblast proliferation; diacylglycerol catabolic process; arachidonic acid metabolic process; blood coagulation; neurotransmitter biosynthetic process
Product References and Citations for anti-DAGLA antibody
Knight, M.A., et al. Hum. Mol. Genet. 17(24):3847-3853(2008) Jung, K.M., et al. Mol. Pharmacol. 68(5):1196-1202(2005) Bisogno, T., et al. J. Cell Biol. 163(3):463-468(2003)
Research Articles on DAGLA
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Products associated with anti-DAGLA antibody
Diseases associated with anti-DAGLA antibody
Organs/Tissues associated with anti-DAGLA antibody
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