NP_001153889.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,220 Da
NCBI Official Full Name
Z-DNA-binding protein 1 isoform b
NCBI Official Synonym Full Names
Z-DNA binding protein 1
NCBI Protein Information
Z-DNA-binding protein 1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; DNA-dependent activator of interferon regulatory factors; tumor stroma and activated macrophage protein DLM-1
UniProt Protein Name
Z-DNA-binding protein 1
UniProt Synonym Protein Names
Tumor stroma and activated macrophage protein DLM-1
UniProt Synonym Gene Names
UniProt Entry Name
ZBP1_HUMAN
NCBI Summary for DAI
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for DAI
ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 20q13.31
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding
Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response
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Products associated with anti-DAI antibody
Pathways associated with anti-DAI antibody
Diseases associated with anti-DAI antibody
Organs/Tissues associated with anti-DAI antibody
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