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anti-DAP12 antibody :: Rabbit anti-Human, Mouse DAP12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS395757
Western Blot/Blotting
Unit / Price
0.1 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAP12, Polyclonal Antibody

★Popular Item★
 Also Known As   

DAP12

 Product Synonym Names    TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; Killer-activating receptor-associated protein; KARAP; TYROBP
 Product Gene Name   

anti-DAP12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000073.6 (30413788..30417582). Location: 7 B; 7 17.45 cM
 3D Structure    ModBase 3D Structure for O54885
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Ammonium Sulfate Precipitation
 Form/Format    Provided as solution in phosphate buffered saline with 0.08% sodium azide
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 Immunogen    Recombinant DAP12 protein
 Positive Control    NKp44 positive cells
 Form    unconjugated
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 Preparation and Storage    Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-DAP12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DAP12 antibody

   DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).
 Product Categories/Family for anti-DAP12 antibody    Polyclonal Antibody; Protein Kinases
 Applications Tested/Suitable for anti-DAP12 antibody   

Western Blot (WB), Immunoprecipitation (IP)

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 Western Blot/Blotting of anti-DAP12 antibody    Immunoprecipitation using DAP12 antibody on MHC class I (1) and NKp44 (2) positive cells.
anti-DAP12 antibody Western Blot/Blotting (WB) image
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NCBI/Uniprot data below describe general gene information for DAP12. It may not necessarily be applicable to this product.
 NCBI GI #    6755915
 NCBI GeneID    22177
 NCBI Accession #    NP_035792.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011662.2 [Other Products]
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 UniProt Primary Accession #    O54885 [Other Products]
 UniProt Secondary Accession #    O88603 [Other Products]
 UniProt Related Accession #    O54885 [Other Products]
 Molecular Weight    12,367 Da
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 NCBI Official Full Name    TYRO protein tyrosine kinase-binding protein
 NCBI Official Synonym Full Names    TYRO protein tyrosine kinase binding protein
 NCBI Official Symbol    Tyrobp [Similar Products]
 NCBI Official Synonym Symbols   
Ly83; DAP12; KARAP
[Similar Products]
 NCBI Protein Information    TYRO protein tyrosine kinase-binding protein; KAR-associated protein; DNAX-activation protein 12; killer-activating receptor-associated protein; killer cell activating receptor associated protein
 UniProt Protein Name    TYRO protein tyrosine kinase-binding protein
 UniProt Synonym Protein Names   
DNAX-activation protein 12; Killer-activating receptor-associated protein
 UniProt Gene Name    Tyrobp [Similar Products]
 UniProt Synonym Gene Names    Dap12; Karap; KAR-associated protein [Similar Products]
 UniProt Entry Name    TYOBP_MOUSE
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 UniProt Comments for DAP12    Function: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Ref.7

Subunit structure: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with SIGLEC14

By similarity. Interacts with CLECSF5. Interacts with CD300LB and CD300D. Interacts with CD300E. Interacts with KLRC2 and KIR2DS3

By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Tyrosine phosphorylated.

Sequence similarities: Belongs to the TYROBP family.Contains 1 ITAM domain.
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 Research Articles on DAP12    1. the Siglec-15-DAP12-Syk-signaling cascade plays a critical role in functional osteoclast formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DAP12 antibodyDiseases associated with anti-DAP12 antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >34 publications with DAP12 and Inflammation
 Neoplasms Antibodies  >28 publications with DAP12 and Neoplasms
 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Antibodies  >19 publications with DAP12 and Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
 Necrosis Antibodies  >17 publications with DAP12 and Necrosis
 Disease Models, Animal Antibodies  >8 publications with DAP12 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >5 publications with DAP12 and Neoplasms, Experimental
 Arteriosclerosis Antibodies  >3 publications with DAP12 and Arteriosclerosis
 Liver Diseases Antibodies  >3 publications with DAP12 and Liver Diseases
 Carcinoma Antibodies  >2 publications with DAP12 and Carcinoma
 Carcinoma, Squamous Cell Antibodies  >1 publications with DAP12 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-DAP12 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >131 publications with DAP12 and Blood
 Bone Antibodies  >68 publications with DAP12 and Bone
 Bone Marrow Antibodies  >26 publications with DAP12 and Bone Marrow
 Brain Antibodies  >24 publications with DAP12 and Brain
 Spleen Antibodies  >14 publications with DAP12 and Spleen
 Lymph Node Antibodies  >6 publications with DAP12 and Lymph Node
 Skin Antibodies  >3 publications with DAP12 and Skin
 Intestine Antibodies  >2 publications with DAP12 and Intestine
 Thymus Antibodies  >1 publications with DAP12 and Thymus
 Embryonic Tissue Antibodies  >1 publications with DAP12 and Embryonic Tissue
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