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anti-DAPK2 antibody :: Rabbit anti-Human DAPK2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7006583
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAPK2, Polyclonal Antibody

★Popular Item★
 Also Known As   

DAPK2 Antibody

 Product Synonym Names    DAP kinase 2; DAP-kinase-related protein 1; DRP-1; DAPK2
 Product Gene Name   

anti-DAPK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    616567
 3D Structure    ModBase 3D Structure for Q9UIK4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Death-associated protein kinase 2 protein(222-370AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10084 / sc-10081 / sc-130734
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DAPK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DAPK2 antibody

   Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
 Applications Tested/Suitable for anti-DAPK2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-DAPK2 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-DAPK2 antibody    Western blot
All lanes: DAPK2 antibody at 6ug/ml+ Mouse brain tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 43,56 kDa
Observed band size: 43 kDa

anti-DAPK2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-DAPK2 antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7006583 at dilution 1:100
anti-DAPK2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DAPK2 antibody    Immunohistochemistry of paraffin-embedded human breast cancer tissue using MBS7006583 at dilution 1:100
anti-DAPK2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DAPK2 antibody    Immunohistochemistry of paraffin-embedded human liver cancer tissue using MBS7006583 at dilution 1:100
anti-DAPK2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-DAPK2 antibody    Immunofluorescent analysis of MCF-7 cells using MBS7006583 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DAPK2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for DAPK2. It may not necessarily be applicable to this product.
 NCBI GI #    14670383
 NCBI GeneID    23604
 NCBI Accession #    NP_055141.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014326.3 [Other Products]
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 UniProt Primary Accession #    Q9UIK4 [Other Products]
 UniProt Secondary Accession #    O75892; Q24JS1; E9JGM7 [Other Products]
 UniProt Related Accession #    Q9UIK4 [Other Products]
 Molecular Weight    55,931 Da
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 NCBI Official Full Name    death-associated protein kinase 2
 NCBI Official Synonym Full Names    death-associated protein kinase 2
 NCBI Official Symbol    DAPK2 [Similar Products]
 NCBI Official Synonym Symbols   
DRP1; DRP-1
[Similar Products]
 NCBI Protein Information    death-associated protein kinase 2
 UniProt Protein Name    Death-associated protein kinase 2
 UniProt Synonym Protein Names   
DAP-kinase-related protein 1; DRP-1
 Protein Family    Death-associated protein kinase
 UniProt Gene Name    DAPK2 [Similar Products]
 UniProt Synonym Gene Names    DAP kinase 2; DRP-1 [Similar Products]
 UniProt Entry Name    DAPK2_HUMAN
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 NCBI Summary for DAPK2    This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DAPK2    DAPK2: an ubiquitously expressed protein kinase of the DAPK family. Activated by Ca(2+)/calmodulin. Contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain. Overexpression induces apoptosis. Expressed at high levels in heart, lung and skeletal muscle.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.1; CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytoplasm; cytoplasmic vesicle

Molecular Function: ATP binding; calmodulin binding; identical protein binding; protein binding; protein serine/threonine kinase activity

Biological Process: anoikis; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of autophagy
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 Research Articles on DAPK2    1. This study links adipocyte expression of an autophagy-regulating kinase, lysosome-mediated clearance and fat cell lipid accumulation; it demonstrates obesity-related attenuated autophagy in adipocytes, and identifies DAPK2 dependence in this regulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DAPK2 antibodyPathways associated with anti-DAPK2 antibody
 Reference Product  PubMed Publications
 DAP antibody  >149 publications with DAPK2 and DAP
 ATF4 antibody  >4 publications with DAPK2 and ATF4
 CAMK2A antibody  >1 publications with DAPK2 and CAMK2A
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Ligand-independent Caspase Activation Via DCC Pathway antibodies  Ligand-independent Caspase Activation Via DCC Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
Diseases associated with anti-DAPK2 antibodyOrgans/Tissues associated with anti-DAPK2 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >68 publications with DAPK2 and Brain Diseases
 Necrosis Antibodies  >61 publications with DAPK2 and Necrosis
 Neoplasm Metastasis Antibodies  >42 publications with DAPK2 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >35 publications with DAPK2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >34 publications with DAPK2 and Breast Neoplasms
 Inflammation Antibodies  >33 publications with DAPK2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >26 publications with DAPK2 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >26 publications with DAPK2 and Disease Models, Animal
 Heart Diseases Antibodies  >15 publications with DAPK2 and Heart Diseases
 Kidney Diseases Antibodies  >12 publications with DAPK2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >107 publications with DAPK2 and Blood
 Brain Antibodies  >80 publications with DAPK2 and Brain
 Lung Antibodies  >75 publications with DAPK2 and Lung
 Vascular Antibodies  >40 publications with DAPK2 and Vascular
 Stomach Antibodies  >32 publications with DAPK2 and Stomach
 Lymph Node Antibodies  >30 publications with DAPK2 and Lymph Node
 Bone Marrow Antibodies  >20 publications with DAPK2 and Bone Marrow
 Prostate Antibodies  >17 publications with DAPK2 and Prostate
 Skin Antibodies  >11 publications with DAPK2 and Skin
 Intestine Antibodies  >9 publications with DAPK2 and Intestine
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