NP_055141.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 42 kDa Predicted: 43 kDa
NCBI Official Full Name
death-associated protein kinase 2 isoform 1
NCBI Official Synonym Full Names
death associated protein kinase 2
NCBI Official Synonym Symbols
NCBI Protein Information
death-associated protein kinase 2
UniProt Protein Name
Death-associated protein kinase 2
UniProt Synonym Protein Names
DAP-kinase-related protein 1; DRP-1
UniProt Synonym Gene Names
NCBI Summary for DAPK2
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
UniProt Comments for DAPK2
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).
Research Articles on DAPK2
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Products associated with anti-DAPK2 antibody
Pathways associated with anti-DAPK2 antibody
Diseases associated with anti-DAPK2 antibody
Organs/Tissues associated with anti-DAPK2 antibody
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