NP_001229393.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,738 Da
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 1B isoform 2
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory (inhibitor) subunit 1B
NCBI Protein Information
protein phosphatase 1 regulatory subunit 1B
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 1B
UniProt Synonym Protein Names
DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein
UniProt Synonym Gene Names
UniProt Entry Name
PPR1B_HUMAN
NCBI Summary for DARPP-32
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for DARPP-32
DARPP-32: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: cell soma; cytoplasm; cytosol; nucleus
Molecular Function: protein kinase inhibitor activity; protein phosphatase type 1 regulator activity; D4 dopamine receptor binding; protein phosphatase inhibitor activity; D1 dopamine receptor binding; type 1 serine/threonine specific protein phosphatase inhibitor activity; D3 dopamine receptor binding; D2 dopamine receptor binding; D5 dopamine receptor binding
Biological Process: negative regulation of female receptivity; transcription, DNA-dependent; regulation of catalytic activity; response to amphetamine; negative regulation of catalytic activity; negative regulation of protein kinase activity; visual learning; signal transduction
Research Articles on DARPP-32
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Products associated with anti-DARPP-32 antibody
Pathways associated with anti-DARPP-32 antibody
Diseases associated with anti-DARPP-32 antibody
Organs/Tissues associated with anti-DARPP-32 antibody
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