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anti-DBC2 antibody :: Rabbit DBC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440073 anti-DBC2 antibody
Unit / Price
0.2 mg  /  $240 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DBC2, Polyclonal Antibody

★Popular Item★
 Also Known As   

DBC2 (N15) Antibody

 Product Gene Name   

anti-DBC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607352
 3D Structure    ModBase 3D Structure for Q9BYZ6
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, rat, human
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 Specificity    Mouse, rat, and human DBC2
 Form/Format    200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.200 mg/ml (lot specific)
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 Origin    DBC2 (N15) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminal domain of human DBC2.
 Immunogen    Synthetic peptide mapping to the amino terminal domain of human DBC2
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-DBC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DBC2 antibody

   Representational difference analysis (RDA) was the technique used to map a region on human chromosome 8p21 that contained a homozygous deletion several of the breast cancer specimens studied (1). The mapping of this region led to the identification of a gene with somatic mutations in breast cancer cells (1). This expression of this gene DBC2 (deleted in breast cancer) was extinguished in about half of the breast and lung cancer specimens that were examined, making it a good tumor suppressor candidate (1). The functional analysis of DBC2 found that expression of DBC2 in breast cancer cells missing DBC2 transcripts resulted growth inhibition (1).
 Applications Tested/Suitable for anti-DBC2 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DBC2. It may not necessarily be applicable to this product.
 NCBI GI #    12667516
 NCBI GeneID    23221
 NCBI Accession #    AAG61157.1 [Other Products]
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 UniProt Primary Accession #    Q9BYZ6 [Other Products]
 UniProt Secondary Accession #    O94825; Q8N4A8; Q9BZK6; A8K9Z8; D3DSR8; E9PBU2; E9PEI7 [Other Products]
 UniProt Related Accession #    Q9BYZ6 [Other Products]
 Molecular Weight    83,469 Da
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 NCBI Official Full Name    DBC2
 NCBI Official Synonym Full Names    Rho-related BTB domain containing 2
 NCBI Official Symbol    RHOBTB2 [Similar Products]
 NCBI Official Synonym Symbols   
DBC2
[Similar Products]
 NCBI Protein Information    rho-related BTB domain-containing protein 2; deleted in breast cancer 2 gene protein; p83
 UniProt Protein Name    Rho-related BTB domain-containing protein 2
 UniProt Synonym Protein Names   
Deleted in breast cancer 2 gene protein; p83
 UniProt Gene Name    RHOBTB2 [Similar Products]
 UniProt Synonym Gene Names    DBC2; KIAA0717 [Similar Products]
 UniProt Entry Name    RHBT2_HUMAN
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 NCBI Summary for DBC2    The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for DBC2    RHOBTB2: is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Protein type: G protein; G protein, monomeric, Rho; G protein, monomeric

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: plasma membrane; cytosol

Molecular Function: GTP binding

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
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Product References and Citations for anti-DBC2 antibody

   1.) Siripurapu V, Meth J, Kobayashi N, Hamaguchi M. 2005. DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. J Mol Biol. Feb 11;346(1):83-9.2.) Yoshihara T, Collado D, Hamaguchi M. 2007, Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function. Biochem Biophys Res Commun. Jul 13;358(4):1076-9.

1. Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH. 2002. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. PNAS USA 99(21):13647-13652.
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 Research Articles on DBC2    1. Mutation in the promoter and exon 7 of DBC2 gene is not common in the Chinese population and may not contribute to the susceptibility for breast cancer in China
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DBC2 antibodyDiseases associated with anti-DBC2 antibody
 Products by Pathway  Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >18 publications with DBC2 and Breast Neoplasms
 Nervous System Diseases Antibodies  >1 publications with DBC2 and Nervous System Diseases
 Necrosis Antibodies  >1 publications with DBC2 and Necrosis
 Peripheral Nervous System Diseases Antibodies  >1 publications with DBC2 and Peripheral Nervous System Diseases
Organs/Tissues associated with anti-DBC2 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with DBC2 and Lung
 Lymph Node Antibodies  >4 publications with DBC2 and Lymph Node
 Lymph Antibodies  >4 publications with DBC2 and Lymph
 Bladder Antibodies  >3 publications with DBC2 and Bladder
 Bone Antibodies  >2 publications with DBC2 and Bone
 Blood Antibodies  >2 publications with DBC2 and Blood
 Stomach Antibodies  >2 publications with DBC2 and Stomach
 Kidney Antibodies  >2 publications with DBC2 and Kidney
 Embryonic Tissue Antibodies  >1 publications with DBC2 and Embryonic Tissue
 Placenta Antibodies  >1 publications with DBC2 and Placenta
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