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anti-CD209 antibody :: Rabbit DC-SIGN (ED) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS194218 anti-CD209 antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DC-SIGN (ED) (CD209), Polyclonal Antibody

 Also Known As   

DC-SIGN (ED) Polyclonal Antibody

 Product Synonym Names    DC-SIGN (ED)
 Product Gene Name   

anti-CD209 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (7804879..7812464, complement). Location: 19p13
 OMIM    604672
 3D Structure    ModBase 3D Structure for Q9NNX6
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    DC-SIGN (ED) [This rabbit antibody recognizes aa 277-203 of human DC-SIGN.]
This antibody recognizes human DCSIGN, a dendritic cell receptor that can capture and transport HIV from mucosal areas to remote lymph nodes where HIV is then transferred to CD4+ T lymphocytes. Multiple strains of HIV-1, HIV-2, and SIV bind to dendritic cells via DC-SIGN. DC-SIGN is expressed in mucosal tissues, placenta, small intestine, and rectum.
 Form/Format    100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to aa 277-293 of human DC-SIGN.
 Stabilizer    None
 Preservatives    0.02% sodium azide
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-CD209 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD209 antibody    Infectious Disease Antibodies
 Applications Tested/Suitable for anti-CD209 antibody   


 Application Notes for anti-CD209 antibody    Immunoblotting: use at 1-2 ug/ml. In immunoblots, a band of 44 kD is detected.
Positive control: Human placenta tissue lysate.
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NCBI/Uniprot data below describe general gene information for CD209. It may not necessarily be applicable to this product.
 NCBI GI #    13383468
 NCBI GeneID    30835
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 UniProt Primary Accession #    Q9NNX6 [Other Products]
 UniProt Secondary Accession #    Q2TB19; Q96QP7; Q96QP8; Q96QP9; Q96QQ0; Q96QQ1; Q96QQ2; Q96QQ3; Q96QQ4; A8KAM4; A8MVQ9 [Other Products]
 UniProt Related Accession #    Q9NNX6 [Other Products]
 Molecular Weight    45,775 Da [Similar Products]
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 NCBI Official Full Name    DC-SIGN
 NCBI Official Synonym Full Names    CD209 molecule
 NCBI Official Symbol    CD209 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
 UniProt Protein Name    CD209 antigen
 UniProt Synonym Protein Names   
C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1
 Protein Family    CD209 antigen
 UniProt Gene Name    CD209 [Similar Products]
 UniProt Synonym Gene Names    CLEC4L [Similar Products]
 UniProt Entry Name    CD209_HUMAN
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 NCBI Summary for CD209    This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
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 UniProt Comments for CD209    CD209: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cell surface; membrane; cytoplasm; plasma membrane; integral to membrane

Molecular Function: mannose binding; protein binding; peptide antigen binding; metal ion binding; virion binding; carbohydrate binding

Biological Process: cell-cell recognition; heterophilic cell adhesion; antigen processing and presentation; leukocyte adhesion; virus-host interaction; regulation of T cell proliferation; innate immune response; endocytosis; peptide antigen transport; viral genome replication; virion attachment to host cell surface receptor

Disease: Mycobacterium Tuberculosis, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on CD209    1. Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD209 antibodyPathways associated with anti-CD209 antibody
 Reference Product  PubMed Publications
 CLEC4M antibody  >11 publications with CD209 and CLEC4M
 ICAM3 antibody  >5 publications with CD209 and ICAM3
 ITGAM antibody  >4 publications with CD209 and ITGAM
 SP1 antibody  >3 publications with CD209 and SP1
 ICAM2 antibody  >1 publications with CD209 and ICAM2
 CEACAM1 antibody  >1 publications with CD209 and CEACAM1
 Products by Pathway  Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-CD209 antibodyOrgans/Tissues associated with anti-CD209 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with CD209 and Inflammation
 Tuberculosis Antibodies  >17 publications with CD209 and Tuberculosis
 Dengue Antibodies  >14 publications with CD209 and Dengue
 Cardiovascular Diseases Antibodies  >4 publications with CD209 and Cardiovascular Diseases
 Metabolic Diseases Antibodies  >3 publications with CD209 and Metabolic Diseases
 Lymphoma, Non-Hodgkin Antibodies  >2 publications with CD209 and Lymphoma, Non-Hodgkin
 Neoplasms, Experimental Antibodies  >2 publications with CD209 and Neoplasms, Experimental
 Colitis Antibodies  >2 publications with CD209 and Colitis
 Colorectal Neoplasms Antibodies  >2 publications with CD209 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >6 publications with CD209 and Placenta
 Brain Antibodies  >6 publications with CD209 and Brain
 Uterus Antibodies  >4 publications with CD209 and Uterus
 Intestine Antibodies  >4 publications with CD209 and Intestine
 Eye Antibodies  >2 publications with CD209 and Eye
 Thymus Antibodies  >2 publications with CD209 and Thymus
 Pancreas Antibodies  >2 publications with CD209 and Pancreas
 Adipose Tissue Antibodies  >1 publications with CD209 and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with CD209 and Connective Tissue
 Pharynx Antibodies  >1 publications with CD209 and Pharynx
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