NP_057440.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
doublecortin domain-containing protein 2
NCBI Official Synonym Full Names
doublecortin domain containing 2
NCBI Protein Information
doublecortin domain-containing protein 2
UniProt Protein Name
Doublecortin domain-containing protein 2
UniProt Synonym Protein Names
Protein RU2S
UniProt Synonym Gene Names
UniProt Entry Name
DCDC2_HUMAN
NCBI Summary for DCDC2
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for DCDC2
DCDC2: May be involved in neuronal migration during development of the cerebral neocortex. Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: cytoplasm
Molecular Function: protein binding
Biological Process: dendrite morphogenesis; neuron migration; positive regulation of smoothened signaling pathway; visual learning; cellular defense response
Disease: Deafness, Autosomal Recessive 66; Nephronophthisis 19
Research Articles on DCDC2
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Products associated with anti-DCDC2 antibody
Diseases associated with anti-DCDC2 antibody
Organs/Tissues associated with anti-DCDC2 antibody
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