NP_689837.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,443 Da
NCBI Official Full Name
Homo sapiens decapping mRNA 2 (DCP2), transcript variant 1, mRNA
NCBI Official Synonym Full Names
decapping mRNA 2
NCBI Official Synonym Symbols
NCBI Protein Information
m7GpppN-mRNA hydrolase; DCP2 decapping enzyme homolog; hDpc; mRNA-decapping enzyme 2; nudix (nucleoside diphosphate linked moiety X)-type motif 20
UniProt Protein Name
m7GpppN-mRNA hydrolase
UniProt Synonym Protein Names
Nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20; mRNA-decapping enzyme 2; hDpc
UniProt Entry Name
DCP2_HUMAN
NCBI Summary for DCP2
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
UniProt Comments for DCP2
DCP2: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety. Belongs to the Nudix hydrolase family. DCP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.1.62; RNA processing; Hydrolase
Chromosomal Location of Human Ortholog: 5q22.2
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytosol; cell junction
Molecular Function: protein binding; m7G(5')pppN diphosphatase activity; exoribonuclease activity, producing 5'-phosphomonoesters; RNA binding; manganese ion binding
Biological Process: mRNA catabolic process; mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA catabolic process, deadenylation-dependent decay
Product References and Citations for anti-DCP2 antibody
(1) Li,Y., Song,M.G. and Kiledjian,M. Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein. Mol. Cell. Biol. 28 (3), 939-948 (2008).
Research Articles on DCP2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-DCP2 antibody
Pathways associated with anti-DCP2 antibody
Diseases associated with anti-DCP2 antibody
Organs/Tissues associated with anti-DCP2 antibody
|