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anti-DCX antibody :: Rabbit anti-Human DCX Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS625822 anti-DCX antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DCX, Polyclonal Antibody

 Also Known As   

DCX (S128) (Neuronal Migration Protein Doublecortin, Lissencephalin-X, Lis-X, Doublin, DBCN, LISX)

 Product Synonym Names    Anti -DCX (S128) (Neuronal Migration Protein Doublecortin, Lissencephalin-X, Lis-X, Doublin, DBCN, LISX)
 Product Gene Name   

anti-DCX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (110537007..110655460, complement). Location: Xq22.3-q23
 OMIM    300067
 3D Structure    ModBase 3D Structure for O43602
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human DCX.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide corresponding to amino acid residues surrounding S128 of human DCX (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-DCX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DCX antibody

   In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
 Product Categories/Family for anti-DCX antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-DCX antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-DCX antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
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NCBI/Uniprot data below describe general gene information for DCX. It may not necessarily be applicable to this product.
 NCBI GI #    2792350
 NCBI GeneID    1641
 NCBI Accession #    AAC31797.1 [Other Products]
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 UniProt Primary Accession #    O43602 [Other Products]
 UniProt Secondary Accession #    O43911; Q5JYZ5; A6NFY6; A9Z1V8; D3DUY8; D3DUY9; D3DUZ0 [Other Products]
 UniProt Related Accession #    O43602 [Other Products]
 Molecular Weight    49,318 Da [Similar Products]
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 NCBI Official Full Name    doublecortin isoform
 NCBI Official Synonym Full Names    doublecortin
 NCBI Official Symbol    DCX [Similar Products]
 NCBI Official Synonym Symbols   
DC; DBCN; LISX; SCLH; XLIS
[Similar Products]
 NCBI Protein Information    neuronal migration protein doublecortin; lis-X; doublin; doublecortex; lissencephalin-X
 UniProt Protein Name    Neuronal migration protein doublecortin
 UniProt Synonym Protein Names   
Doublin; Lissencephalin-X
 Protein Family    Protein doublecortin
 UniProt Gene Name    DCX [Similar Products]
 UniProt Synonym Gene Names    DBCN; LISX; Lis-X [Similar Products]
 UniProt Entry Name    DCX_HUMAN
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 NCBI Summary for DCX    This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
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 UniProt Comments for DCX    Doublecortin: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Interacts with tubulin. Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: microtubule; neuron projection; microtubule associated complex; cytoskeleton; cytosol

Molecular Function: protein binding; microtubule binding; protein kinase binding

Biological Process: axon guidance; nervous system development; central nervous system development; axon extension; dendrite morphogenesis; neuron migration; central nervous system projection neuron axonogenesis; brain development

Disease: Lissencephaly, X-linked, 1
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 Research Articles on DCX    1. This finding points to the possible implication of mosaic deletions in the DCX gene in unexplained forms of subcortical band heterotopia (SBH) and may allow for detection of SBH prenatally.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DCX antibodyPathways associated with anti-DCX antibody
 Reference Product  PubMed Publications
 GFAP antibody  >89 publications with DCX and GFAP
 PAFAH1B1 antibody  >48 publications with DCX and PAFAH1B1
 CDK5 antibody  >8 publications with DCX and CDK5
 MAPK8 antibody  >2 publications with DCX and MAPK8
 NES antibody  >1 publications with DCX and NES
 RBFOX3 antibody  >1 publications with DCX and RBFOX3
 MARK2 antibody  >1 publications with DCX and MARK2
 NFASC antibody  >1 publications with DCX and NFASC
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Neurofascin Interactions Pathway antibodies  Neurofascin Interactions Pathway Diagram
Diseases associated with anti-DCX antibodyOrgans/Tissues associated with anti-DCX antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >216 publications with DCX and Brain Diseases
 Cardiovascular Diseases Antibodies  >84 publications with DCX and Cardiovascular Diseases
 Neoplasms Antibodies  >41 publications with DCX and Neoplasms
 Movement Disorders Antibodies  >24 publications with DCX and Movement Disorders
 Inflammation Antibodies  >20 publications with DCX and Inflammation
 Neurobehavioral Manifestations Antibodies  >19 publications with DCX and Neurobehavioral Manifestations
 Brain Injuries Antibodies  >17 publications with DCX and Brain Injuries
 LISSENCEPHALY, X-LINKED, 1 Antibodies  >17 publications with DCX and LISSENCEPHALY, X-LINKED, 1
 Cognition Disorders Antibodies  >14 publications with DCX and Cognition Disorders
 Memory Disorders Antibodies  >13 publications with DCX and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >647 publications with DCX and Brain
 Vascular Antibodies  >29 publications with DCX and Vascular
 Embryonic Tissue Antibodies  >24 publications with DCX and Embryonic Tissue
 Eye Antibodies  >17 publications with DCX and Eye
 Muscle Antibodies  >10 publications with DCX and Muscle
 Mouth Antibodies  >3 publications with DCX and Mouth
 Testis Antibodies  >2 publications with DCX and Testis
 Lung Antibodies  >2 publications with DCX and Lung
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