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anti-DDIT4 antibody :: Rabbit anti-Human DDIT4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7050976
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DDIT4, Polyclonal Antibody

★Popular Item★
 Also Known As   

DDIT4 Antibody

 Product Synonym Names    DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1; DDIT4; REDD1; RTP801
 Product Gene Name   

anti-DDIT4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AY090097 mRNA
 3D Structure    ModBase 3D Structure for Q9NX09
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human DNA damage-inducible transcript 4 protein (1-163AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46034 / sc-46033 / sc-67051
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DDIT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DDIT4 antibody

   Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
 Applications Tested/Suitable for anti-DDIT4 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-DDIT4 antibody    IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Immunohistochemistry (IHC) of anti-DDIT4 antibody    Immunohistochemistry of paraffin-embedded human liver cancer tissue using MBS7050976 at dilution of 1:100
anti-DDIT4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-DDIT4 antibody    Immunofluorescent analysis of Hela cells using MBS7050976 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DDIT4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for DDIT4. It may not necessarily be applicable to this product.
 NCBI GI #    9506687
 NCBI GeneID    54541
 NCBI Accession #    NP_061931.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019058.3 [Other Products]
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 UniProt Primary Accession #    Q9NX09 [Other Products]
 UniProt Secondary Accession #    Q9H0S3 [Other Products]
 UniProt Related Accession #    Q9NX09 [Other Products]
 Molecular Weight    25,371 Da
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 NCBI Official Full Name    DNA damage-inducible transcript 4 protein
 NCBI Official Synonym Full Names    DNA damage inducible transcript 4
 NCBI Official Symbol    DDIT4 [Similar Products]
 NCBI Official Synonym Symbols   
Dig2; REDD1; REDD-1
[Similar Products]
 NCBI Protein Information    DNA damage-inducible transcript 4 protein
 UniProt Protein Name    DNA damage-inducible transcript 4 protein
 UniProt Synonym Protein Names   
HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1
 Protein Family    DNA damage-inducible transcript 4 protein
 UniProt Gene Name    DDIT4 [Similar Products]
 UniProt Synonym Gene Names    REDD1; RTP801; REDD-1 [Similar Products]
 UniProt Entry Name    DDIT4_HUMAN
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 UniProt Comments for DDIT4    DDIT4: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family.

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: cytoplasm; cytosol; intracellular

Biological Process: brain development; cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of peptidyl-serine phosphorylation; negative regulation of TOR signaling pathway; nerve growth factor receptor signaling pathway; neuron differentiation; neuron migration; response to hypoxia
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 Research Articles on DDIT4    1. findings implicate REDD1 as a crucial regulator of mTORC1 activity in iron-depleted cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DDIT4 antibodyPathways associated with anti-DDIT4 antibody
 Reference Product  PubMed Publications
 MTOR antibody  >92 publications with DDIT4 and MTOR
 TSC2 antibody  >27 publications with DDIT4 and TSC2
 TSC1 antibody  >17 publications with DDIT4 and TSC1
 TP53 antibody  >4 publications with DDIT4 and TP53
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 TP53 Regulates Metabolic Genes Pathway antibodies  TP53 Regulates Metabolic Genes Pathway Diagram
 Target Of Rapamycin (TOR) Signaling Pathway antibodies  Target Of Rapamycin (TOR) Signaling Pathway Diagram
 Transcriptional Regulation By TP53 Pathway antibodies  Transcriptional Regulation By TP53 Pathway Diagram
Diseases associated with anti-DDIT4 antibodyOrgans/Tissues associated with anti-DDIT4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with DDIT4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >14 publications with DDIT4 and Disease Models, Animal
 Breast Neoplasms Antibodies  >12 publications with DDIT4 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >10 publications with DDIT4 and Cardiovascular Diseases
 Leukemia Antibodies  >9 publications with DDIT4 and Leukemia
 Inflammation Antibodies  >8 publications with DDIT4 and Inflammation
 Lung Neoplasms Antibodies  >8 publications with DDIT4 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with DDIT4 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >5 publications with DDIT4 and Liver Diseases
 Parkinson Disease Antibodies  >4 publications with DDIT4 and Parkinson Disease
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >31 publications with DDIT4 and Muscle
 Blood Antibodies  >27 publications with DDIT4 and Blood
 Brain Antibodies  >20 publications with DDIT4 and Brain
 Liver Antibodies  >14 publications with DDIT4 and Liver
 Lung Antibodies  >12 publications with DDIT4 and Lung
 Bone Antibodies  >10 publications with DDIT4 and Bone
 Heart Antibodies  >7 publications with DDIT4 and Heart
 Prostate Antibodies  >7 publications with DDIT4 and Prostate
 Nerve Antibodies  >6 publications with DDIT4 and Nerve
 Vascular Antibodies  >6 publications with DDIT4 and Vascular
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