NP_001136021.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,056 Da
NCBI Official Full Name
probable ATP-dependent RNA helicase DDX4 isoform 2
NCBI Official Synonym Full Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
NCBI Official Synonym Symbols
NCBI Protein Information
probable ATP-dependent RNA helicase DDX4; DEAD box protein 4; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4; vasa homolog
UniProt Protein Name
Probable ATP-dependent RNA helicase DDX4
UniProt Synonym Protein Names
DEAD box protein 4; Vasa homolog
UniProt Synonym Gene Names
UniProt Entry Name
DDX4_HUMAN
NCBI Summary for DDX4
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for DDX4
DDX4: May play a role in germ cell development. May play a role in sperm motility. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Helicase; EC 3.6.4.13
Chromosomal Location of Human Ortholog: 5p15.2-p13.1
Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: nucleic acid binding; helicase activity; ATP binding
Biological Process: sperm motility; regulation of protein localization; male meiosis I; multicellular organismal development; spermatogenesis; gene expression
Research Articles on DDX4
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Products associated with anti-DDX4 antibody
Pathways associated with anti-DDX4 antibody
Diseases associated with anti-DDX4 antibody
Organs/Tissues associated with anti-DDX4 antibody
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