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anti-DDX41 antibody :: Goat DDX41 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS423285
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DDX41, Polyclonal Antibody

 Also Known As   

Goat anti-DDX41 (aa468-480) Antibody

 Product Synonym Names    DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; ABS; 2900024F02Rik; DEAD box protein 41; DEAD box protein abstrakt homolog; DEAD-box protein abstrakt; probable ATP-dependent RNA helicase DDX41; putative RNA helicase; DDX41 antibody; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 antibody; ABS antibody; 2900024F02Rik antibody; DEAD box protein 41 antibody; DEAD box protein abstrakt homolog antibody; DEAD-box protein abstrakt antibody; probable ATP-dependent RNA helicase DDX41 antibody; putative RNA helicase antibody; DDX41 (aa468-480)
 Product Gene Name   

anti-DDX41 antibody

[Similar Products]
 Antibody/Peptide Pairs    DDX41 peptide (MBS428622) is used for blocking the activity of DDX41 antibody (MBS423285)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QEERTKAIEA FRE
 OMIM    608170
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QEERTKAIEAFRE, from the internal region of the protein sequence according to NP_057306.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DDX41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DDX41 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-DDX41 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 85kDa band observed in Human Bone Marrow lysates (calculated MW of 69.8kDa according to NP_057306.2). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0.5-2ug/ml.
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 Western Blot (WB) of anti-DDX41 antibody    (0.5ug/ml) staining of Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DDX41 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DDX41. It may not necessarily be applicable to this product.
 NCBI GI #    21071032
 NCBI GeneID    51428
 NCBI Accession #    NP_057306.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016222.3 [Other Products]
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 UniProt Secondary Accession #    Q96BK6; Q96K05; Q9NT96; Q9NW04; B2RDC8 [Other Products]
 UniProt Related Accession #    Q9UJV9 [Other Products]
 Molecular Weight    69,838 Da
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 NCBI Official Full Name    probable ATP-dependent RNA helicase DDX41 isoform 1
 NCBI Official Synonym Full Names    DEAD-box helicase 41
 NCBI Official Symbol    DDX41 [Similar Products]
 NCBI Official Synonym Symbols   
ABS; MPLPF
[Similar Products]
 NCBI Protein Information    probable ATP-dependent RNA helicase DDX41
 UniProt Protein Name    Probable ATP-dependent RNA helicase DDX41
 UniProt Synonym Protein Names   
DEAD box protein 41; DEAD box protein abstrakt homolog
 Protein Family    Probable ATP-dependent RNA helicase
 UniProt Gene Name    DDX41 [Similar Products]
 UniProt Synonym Gene Names    ABS [Similar Products]
 UniProt Entry Name    DDX41_HUMAN
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 NCBI Summary for DDX41    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DDX41    DDX41: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DDX41 subfamily.

Protein type: RNA-binding; Helicase; Spliceosome; RNA splicing; EC 3.6.4.13

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cytosol; endoplasmic reticulum; membrane

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; DNA binding; metal ion binding; protein binding

Biological Process: apoptosis; defense response to virus; multicellular organismal development; nuclear mRNA splicing, via spliceosome; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; regulation of interferon type I production; RNA processing; RNA secondary structure unwinding
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 Research Articles on DDX41    1. corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DDX41 antibodyDiseases associated with anti-DDX41 antibody
 Products by Pathway  Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IRF3-mediated Induction Of Type I IFN Pathway antibodies  IRF3-mediated Induction Of Type I IFN Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Innate Immune Responses To Cytosolic DNA Pathway antibodies  Regulation Of Innate Immune Responses To Cytosolic DNA Pathway Diagram
 STING Mediated Induction Of Host Immune Responses Pathway antibodies  STING Mediated Induction Of Host Immune Responses Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with DDX41 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with DDX41 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >1 publications with DDX41 and Heart Diseases
 Kidney Diseases Antibodies  >1 publications with DDX41 and Kidney Diseases
 Necrosis Antibodies  >1 publications with DDX41 and Necrosis
Organs/Tissues associated with anti-DDX41 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with DDX41 and Blood
 Bone Antibodies  >4 publications with DDX41 and Bone
 Bone Marrow Antibodies  >4 publications with DDX41 and Bone Marrow
 Liver Antibodies  >2 publications with DDX41 and Liver
 Kidney Antibodies  >2 publications with DDX41 and Kidney
 Stomach Antibodies  >2 publications with DDX41 and Stomach
 Heart Antibodies  >1 publications with DDX41 and Heart
 Prostate Antibodies  >1 publications with DDX41 and Prostate
 Skin Antibodies  >1 publications with DDX41 and Skin
 Lung Antibodies  >1 publications with DDX41 and Lung
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