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anti-DEFA6 antibody :: Rabbit anti-Human DEFA6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524315
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DEFA6, Polyclonal Antibody

★Popular Item★
 Also Known As   

DEFA6 Polyclonal Antibody

 Product Synonym Names    DEF6; HD-6
 Product Gene Name   

anti-DEFA6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600471
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human DEFA6
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DEFA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DEFA6 antibody

   Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8.
 Applications Tested/Suitable for anti-DEFA6 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-DEFA6 antibody    IHC: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-DEFA6 antibody    Immunohistochemistry of paraffin-embedded Human brain tissue using DEFA6 Polyclonal Antibody at dilution 1:40
anti-DEFA6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DEFA6. It may not necessarily be applicable to this product.
 NCBI GI #    4503305
 NCBI GeneID    1671
 NCBI Accession #    BC069667 [Other Products]
 NCBI GenBank Nucleotide #    NM_001926.3 [Other Products]
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 UniProt Secondary Accession #    Q6EZF9 [Other Products]
 UniProt Related Accession #    Q01524 [Other Products]
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 NCBI Official Full Name    defensin-6 preproprotein
 NCBI Official Synonym Full Names    defensin, alpha 6, Paneth cell-specific
 NCBI Official Symbol    DEFA6 [Similar Products]
 NCBI Official Synonym Symbols   
DEF6; HD-6
[Similar Products]
 NCBI Protein Information    defensin-6; defensin 6
 UniProt Protein Name    Defensin-6
 UniProt Synonym Protein Names   
Defensin, alpha 6
 Protein Family    Defensin
 UniProt Gene Name    DEFA6 [Similar Products]
 UniProt Synonym Gene Names    DEF6 [Similar Products]
 UniProt Entry Name    DEF6_HUMAN
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 NCBI Summary for DEFA6    Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]
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 UniProt Comments for DEFA6    defensin, alpha 6: Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1. Belongs to the alpha-defensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
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 Research Articles on DEFA6    1. In the meta-analysis, DEFA6 rs13275170 and DEFB1 rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DEFA6 antibodyPathways associated with anti-DEFA6 antibody
 Reference Product  PubMed Publications
 DEFA5 antibody  >12 publications with DEFA6 and DEFA5
 DEFB1 antibody  >5 publications with DEFA6 and DEFB1
 DEFA4 antibody  >2 publications with DEFA6 and DEFA4
 Products by Pathway  Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with anti-DEFA6 antibodyOrgans/Tissues associated with anti-DEFA6 antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Diseases Antibodies  >12 publications with DEFA6 and Gastrointestinal Diseases
 Intestinal Diseases Antibodies  >12 publications with DEFA6 and Intestinal Diseases
 Colitis, Ulcerative Antibodies  >5 publications with DEFA6 and Colitis, Ulcerative
 Necrosis Antibodies  >1 publications with DEFA6 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >1 publications with DEFA6 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >9 publications with DEFA6 and Intestine
 Stomach Antibodies  >1 publications with DEFA6 and Stomach
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