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anti-KIAA0141 antibody :: Rabbit anti-Human, Rat DELE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151106
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DELE (KIAA0141), Polyclonal Antibody

 Also Known As   

DELE Antibody

 Product Synonym Names    DELE; DELE; DELE; Death ligand signal enhancer; KIAA0141
 Product Gene Name   

anti-KIAA0141 antibody

[Similar Products]
 Antibody/Peptide Pairs    DELE peptide (MBS151815) is used for blocking the activity of DELE antibody (MBS151106)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615741
 3D Structure    ModBase 3D Structure for Q14154
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    DELE Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.
 Buffer    DELE Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    DELE antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-KIAA0141 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KIAA0141 antibody

   DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
 Applications Tested/Suitable for anti-KIAA0141 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-KIAA0141 antibody    DELE antibody can be used for detection of DELE by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-KIAA0141 antibody    Western blot analysis of DELE in rat brain tissue lysate with DELE antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
anti-KIAA0141 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-KIAA0141 antibody    Immunofluorescence of DELE in human brain tissue with DELE antibody at 20 μg/mL.
anti-KIAA0141 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KIAA0141. It may not necessarily be applicable to this product.
 NCBI GI #    217330656
 NCBI GeneID    9812
 NCBI Accession #    NP_055588 [Other Products]
 NCBI GenBank Nucleotide #    NM_014773.4 [Other Products]
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 UniProt Primary Accession #    Q14154 [Other Products]
 UniProt Secondary Accession #    Q969R4; Q96EU9 [Other Products]
 UniProt Related Accession #    Q14154 [Other Products]
 Molecular Weight    55,920 Da
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 NCBI Official Full Name    death ligand signal enhancer
 NCBI Official Synonym Full Names    KIAA0141
 NCBI Official Symbol    KIAA0141 [Similar Products]
 NCBI Official Synonym Symbols   
DELE
[Similar Products]
 NCBI Protein Information    death ligand signal enhancer
 UniProt Protein Name    Death ligand signal enhancer
 Protein Family    Deleted in azoospermia
 UniProt Gene Name    KIAA0141 [Similar Products]
 UniProt Synonym Gene Names    DELE [Similar Products]
 UniProt Entry Name    DELE_HUMAN
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 UniProt Comments for KIAA0141    KIAA0141: Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: mitochondrion

Molecular Function: protein binding

Biological Process: induction of apoptosis via death domain receptors; regulation of caspase activity
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 Research Articles on KIAA0141    1. identifies a novel DAP3-binding protein termed death ligand signal enhancer (DELE); demonstrates the biological significance of DELE for apoptosis signal mediated by death receptors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-KIAA0141 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with KIAA0141 and Necrosis
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