Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Dll1 rightarrow Polyclonal Dll1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Neutrophil Cytosol Factor 1 (Phospho-Ser328) (NCF1) Antibody
 • LAMA5 Antibody
 • Growth Factor Receptor Bound Protein 14 (GRB14) ELISA Kit
 • Immune Ribonucleic Acid-Immune Rna (IRNA) ELISA Kit
 • Fibroblast Growth Factor 2 (FGF-2) ELISA Kit
 • Caveolin 1 (CAV1) ELISA Kit
 • Dehydroepiandrosterone Sulfate (DEHA-S) ELISA Kit
 • Interferon Antibody (IFN) ELISA Kit
 • Mannose Binding Lectin C (MBL-C) ELISA Kit
 • CXC-Chemokine Receptor 2 (CXCR2) ELISA Kit
 • Glutamic Pyruvic Transaminase (GPT) ELISA Kit
 • Complement Component 2 (C2) ELISA Kit
 • Acetylcholine (ACH) ELISA Kit
 • Bone Morphogenetic Protein 2 (BMP2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Dll1 antibody :: Rabbit DELTA-LIKE PROTEIN 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223595
Testing Data #1
Unit / Price
0.05 mg  /  $650 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DELTA-LIKE PROTEIN 1 (Dll1), Polyclonal Antibody

 Also Known As   

RABBIT ANTI DELTA-LIKE PROTEIN 1

 Product Gene Name   

anti-Dll1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for Q61483
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Chicken, Human, Rat
Section Bar
 Specificity    This item specifically recognises Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.

The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression.

Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation.

DLL1 is widely expressed, and acts as a mediator of cell fate decisions during hematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signaling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB).

This item has been reported to work in ELISA.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
Section Bar
 Perservative Stabilisers    0.01% Sodium Azide (NaN3)
 Immunogen    Synthetic peptide sequence corresponding amino acids 155-173 of Mouse Delta-like protein 1.
Histology Positive Control Tissue
 Antiserum Preparation    Antisera to Human DLL1 were raised by repeated immunisation of Rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
 Target Species    Mouse
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Dll1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-Dll1 antibody

   MBS223595 specifically recognises Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL1 is widely expressed, and acts as a mediator of cell fate decisions during hematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signaling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB). MBS223595 has been reported to work in ELISA.
 Applications Tested/Suitable for anti-Dll1 antibody   

Immunohistology Paraffin*

 Application Notes for anti-Dll1 antibody    Immunohistology - Paraffin: Maximum Dilution: 10ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Section Bar
 Testing Data #1 of anti-Dll1 antibody    Staining of formalin fixed, paraffin embedded human brain with Rabbit anti Human DLL1 (MBS223595)
anti-Dll1 antibody Testing Data #1 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Dll1. It may not necessarily be applicable to this product.
 NCBI GI #    40789272
 NCBI GeneID    13388
 NCBI Accession #    NP_031891.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007865.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q61483 [Other Products]
 UniProt Secondary Accession #    Q6PFV7 [Other Products]
 UniProt Related Accession #    Q61483 [Other Products]
 Molecular Weight    78,449 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    delta-like protein 1
 NCBI Official Synonym Full Names    delta-like 1 (Drosophila)
 NCBI Official Symbol    Dll1 [Similar Products]
 NCBI Official Synonym Symbols   
Delta1
[Similar Products]
 NCBI Protein Information    delta-like protein 1; delta like-1; drosophila Delta homolog 1
 UniProt Protein Name    Delta-like protein 1
 UniProt Synonym Protein Names   
Drosophila Delta homolog 1; Delta1
 Protein Family    Delta-like protein
 UniProt Gene Name    Dll1 [Similar Products]
 UniProt Synonym Gene Names    Delta1 [Similar Products]
 UniProt Entry Name    DLL1_MOUSE
Section Bar
 UniProt Comments for Dll1    DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: membrane; plasma membrane; integral to membrane; cytoplasmic vesicle

Molecular Function: protein binding; calcium ion binding; Notch binding

Biological Process: nervous system development; somitogenesis; Notch signaling pathway; inner ear morphogenesis; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; in utero embryonic development; multicellular organismal development; auditory receptor cell differentiation; odontogenesis of dentine-containing teeth; compartment specification; negative regulation of cell differentiation; somite specification; organ morphogenesis; negative regulation of neuron differentiation; regulation of neurogenesis; cell-cell signaling; negative regulation of auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; cell communication; heart looping; determination of left/right symmetry; cell differentiation; auditory receptor cell fate commitment; inner ear development; positive regulation of Notch signaling pathway
Table BarTOPTable Bar
 Research Articles on Dll1    1. Spatiotemporal expression oscillations of Notch1 and Dll1 are coordinated across the mouse pre-somitic mesoderm.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-Dll1 antibodyPathways associated with anti-Dll1 antibody
 Reference Product  PubMed Publications
 Notch1 antibody  >107 publications with Dll1 and Notch1
 Dll4 antibody  >65 publications with Dll1 and Dll4
 Notch2 antibody  >38 publications with Dll1 and Notch2
 Jag1 antibody  >34 publications with Dll1 and Jag1
 Hes5 antibody  >25 publications with Dll1 and Hes5
 Notch3 antibody  >16 publications with Dll1 and Notch3
 Adam10 antibody  >3 publications with Dll1 and Adam10
 Psen1 antibody  >3 publications with Dll1 and Psen1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-Dll1 antibodyOrgans/Tissues associated with anti-Dll1 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >11 publications with Dll1 and Congenital Abnormalities
 Inflammation Antibodies  >9 publications with Dll1 and Inflammation
 Disease Models, Animal Antibodies  >9 publications with Dll1 and Disease Models, Animal
 Carcinoma Antibodies  >9 publications with Dll1 and Carcinoma
 Nervous System Diseases Antibodies  >8 publications with Dll1 and Nervous System Diseases
 Necrosis Antibodies  >5 publications with Dll1 and Necrosis
 Abnormalities, Multiple Antibodies  >5 publications with Dll1 and Abnormalities, Multiple
 Carcinoma, Squamous Cell Antibodies  >4 publications with Dll1 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >4 publications with Dll1 and Lung Diseases
 Hyperplasia Antibodies  >3 publications with Dll1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >41 publications with Dll1 and Embryonic Tissue
 Brain Antibodies  >37 publications with Dll1 and Brain
 Lung Antibodies  >15 publications with Dll1 and Lung
 Spinal Cord Antibodies  >11 publications with Dll1 and Spinal Cord
 Pancreas Antibodies  >8 publications with Dll1 and Pancreas
 Kidney Antibodies  >7 publications with Dll1 and Kidney
 Eye Antibodies  >6 publications with Dll1 and Eye
 Inner Ear Antibodies  >5 publications with Dll1 and Inner Ear
 Lymph Node Antibodies  >3 publications with Dll1 and Lymph Node
 Dorsal Root Ganglion Antibodies  >2 publications with Dll1 and Dorsal Root Ganglion
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions