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anti-DES antibody :: Goat DES / Desmin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243304
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DES / Desmin, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human DES / Desmin

 Product Synonym Names    Anti-DES / Desmin Antibody (C-Terminus) IHC-plus; DES; ARVC7; ARVD7; CMD1I; CSM1; CSM2; MFM1; SCPNK; Desmin; Intermediate filament protein; Human DES; Desmin
 Product Gene Name   

anti-DES antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615325
 3D Structure    ModBase 3D Structure for P17661
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
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 Specificity    Human DES / Desmin.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-RDGEVVSEATQQQHE from the C-terminus of human DES / Desmin (NP_001918.3).
 Immunogen Type    Synthetic peptide
 Immunogen    DES / Desmin antibody was raised against synthetic peptide C-RDGEVVSEATQQQHE from the C-terminus of human DES / Desmin (NP_001918.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Shrew, Hamster, Elephant, Panda, Bat, Bovine, Dog, Rabbit, Horse, Pig, Opossum, Turkey, Chicken, Armadillo (100%); Lizard (93%); Xenopus (80%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-DES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DES antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-DES antibody    ELISA (1:2000), IHC-P (3.75 ug/ml), WB (0.1 - 0.3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:2000. Western Blot: Approx. 55kD band observed in Human Skeletal Muscle lysates (calculated MW of 53.5kD according to NP_001918.3). Recommended concentration: 0.1-0.3 ug/ml.
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 Immunohistochemistry (IHC) of anti-DES antibody    Anti-DES / Desmin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-DES antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DES antibody    Anti-DES / Desmin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-DES antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-DES antibody    Antibody (0.2 ug/ml) staining of Human Skeletal Muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DES antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DES. It may not necessarily be applicable to this product.
 NCBI GI #    55749932
 NCBI GeneID    1674
 NCBI Accession #    NP_001918.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001927.3 [Other Products]
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 UniProt Primary Accession #    P17661 [Other Products]
 UniProt Secondary Accession #    Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99 [Other Products]
 UniProt Related Accession #    P17661 [Other Products]
 Molecular Weight    53,536 Da
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 NCBI Official Full Name    desmin
 NCBI Official Synonym Full Names    desmin
 NCBI Official Symbol    DES [Similar Products]
 NCBI Official Synonym Symbols   
CSM1; CSM2; LGMD2R
[Similar Products]
 NCBI Protein Information    desmin; mutant desmin p.K241E; intermediate filament protein
 UniProt Protein Name    Desmin
 Protein Family    Desmin
 UniProt Gene Name    DES [Similar Products]
 UniProt Entry Name    DESM_HUMAN
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 NCBI Summary for DES    This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DES    desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: intermediate filament; fascia adherens; Z disc; cytosol; neuromuscular junction; sarcolemma

Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding

Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r
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 Research Articles on DES    1. Data suggest that loss of the desmin-p. A120D filament localization at the intercalated disk indicates its clinical arrhythmogenic potential.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DES antibodyDiseases associated with anti-DES antibody
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9274 publications with DES and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >9249 publications with DES and Cardiovascular Diseases
 Heart Diseases Antibodies  >5425 publications with DES and Heart Diseases
 Carcinoma Antibodies  >3686 publications with DES and Carcinoma
 Inflammation Antibodies  >3492 publications with DES and Inflammation
 Pain Antibodies  >2998 publications with DES and Pain
 Liver Diseases Antibodies  >2403 publications with DES and Liver Diseases
 Thrombosis Antibodies  >2285 publications with DES and Thrombosis
 Disease Models, Animal Antibodies  >2178 publications with DES and Disease Models, Animal
 Adenocarcinoma Antibodies  >1928 publications with DES and Adenocarcinoma
Organs/Tissues associated with anti-DES antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18194 publications with DES and Blood
 Brain Antibodies  >9267 publications with DES and Brain
 Vascular Antibodies  >5663 publications with DES and Vascular
 Muscle Antibodies  >5302 publications with DES and Muscle
 Heart Antibodies  >5089 publications with DES and Heart
 Liver Antibodies  >4781 publications with DES and Liver
 Bone Antibodies  >4246 publications with DES and Bone
 Lung Antibodies  >3319 publications with DES and Lung
 Skin Antibodies  >3290 publications with DES and Skin
 Nerve Antibodies  >2853 publications with DES and Nerve
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