NP_073557
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
82,750 Da
NCBI Official Full Name
microprocessor complex subunit DGCR8 isoform 1
NCBI Official Synonym Full Names
DGCR8, microprocessor complex subunit
NCBI Protein Information
microprocessor complex subunit DGCR8
UniProt Protein Name
Microprocessor complex subunit DGCR8
UniProt Synonym Protein Names
DiGeorge syndrome critical region 8
UniProt Synonym Gene Names
NCBI Summary for DGCR8
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
UniProt Comments for DGCR8
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal ().
Product References and Citations for anti-DGCR8 antibody
(1) Shiohama, A., Sasaki, T., Noda, S., et al. Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins.Exp. Cell Res. 2007; 313 (20):4196-4207.
Research Articles on DGCR8
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Products associated with anti-DGCR8 antibody
Pathways associated with anti-DGCR8 antibody
Diseases associated with anti-DGCR8 antibody
Organs/Tissues associated with anti-DGCR8 antibody
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