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anti-DHAND antibody :: Rabbit anti-Human DHAND / HAND2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241029
Immunohistochemistry (IHC)
Unit / Price
  DISCONTINUED
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DHAND / HAND2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human DHAND / HAND2

 Product Synonym Names    Anti-DHAND / HAND2 Antibody (aa194-207) IHC-plus; HAND2; DHand; DHAND2; Hed; Thing2; BHLHa26; Human DHAND; HAND2
 Product Gene Name   

anti-DHAND antibody

[Similar Products]
 Product Synonym Gene Name    HAND2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602407
 3D Structure    ModBase 3D Structure for P61296
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Amino acids 194 to 207 of human HAND2
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human HAND2.
 Immunogen Type    Synthetic peptide
 Immunogen    DHAND / HAND2 antibody was raised against synthetic peptide from human HAND2.
 Antigen Modification    aa194-207
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-DHAND antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DHAND antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-DHAND antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-DHAND antibody    Anti-HAND2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-DHAND antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DHAND. It may not necessarily be applicable to this product.
 NCBI GI #    12545384
 NCBI GeneID    9464
 NCBI Accession #    NP_068808.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021973.2 [Other Products]
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 UniProt Primary Accession #    P61296 [Other Products]
 UniProt Secondary Accession #    O95300; O95301; P97833; Q494T1; B6ECG9 [Other Products]
 UniProt Related Accession #    P61296 [Other Products]
 Molecular Weight    20,269 Da
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 NCBI Official Full Name    heart- and neural crest derivatives-expressed protein 2
 NCBI Official Synonym Full Names    heart and neural crest derivatives expressed 2
 NCBI Official Symbol    HAND2 [Similar Products]
 NCBI Official Synonym Symbols   
Hed; dHand; DHAND2; Thing2; bHLHa26
[Similar Products]
 NCBI Protein Information    heart- and neural crest derivatives-expressed protein 2; class A basic helix-loop-helix protein 26; basic helix-loop-helix transcription factor HAND2; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
 UniProt Protein Name    Heart- and neural crest derivatives-expressed protein 2
 UniProt Synonym Protein Names   
Class A basic helix-loop-helix protein 26; bHLHa26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND
 UniProt Gene Name    HAND2 [Similar Products]
 UniProt Synonym Gene Names    BHLHA26; DHAND; bHLHa26; dHAND [Similar Products]
 UniProt Entry Name    HAND2_HUMAN
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 NCBI Summary for DHAND    The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DHAND    HAND2: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: transcription factor complex; protein complex; nuclear chromatin

Molecular Function: protein binding; protein homodimerization activity; transcription activator binding; AT DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding

Biological Process: adult heart development; heart morphogenesis; tongue development; neural crest cell development; thymus development; transcription, DNA-dependent; in utero embryonic development; apoptosis; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; heart development; mesenchymal cell proliferation; palate development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; peripheral nervous system neuron development; sympathetic nervous system development; regulation of transcription, DNA-dependent; suckling behavior; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast differentiation; angiogenesis; heart looping; embryonic digit morphogenesis
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 Research Articles on DHAND    1. suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DHAND antibodyPathways associated with anti-DHAND antibody
 Reference Product  PubMed Publications
 SHH antibody  >27 publications with DHAND and SHH
 GATA4 antibody  >27 publications with DHAND and GATA4
 MEF2C antibody  >20 publications with DHAND and MEF2C
 GLI3 antibody  >19 publications with DHAND and GLI3
 EDN1 antibody  >16 publications with DHAND and EDN1
 DLX6 antibody  >9 publications with DHAND and DLX6
 MSX1 antibody  >7 publications with DHAND and MSX1
 HOXD13 antibody  >7 publications with DHAND and HOXD13
 TCF3 antibody  >5 publications with DHAND and TCF3
 RUNX2 antibody  >2 publications with DHAND and RUNX2
 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
Diseases associated with anti-DHAND antibodyOrgans/Tissues associated with anti-DHAND antibody
 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >42 publications with DHAND and Heart Defects, Congenital
 Craniofacial Abnormalities Antibodies  >25 publications with DHAND and Craniofacial Abnormalities
 Limb Deformities, Congenital Antibodies  >16 publications with DHAND and Limb Deformities, Congenital
 Embryo Loss Antibodies  >15 publications with DHAND and Embryo Loss
 Nervous System Diseases Antibodies  >6 publications with DHAND and Nervous System Diseases
 Carcinoma Antibodies  >6 publications with DHAND and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with DHAND and Adenocarcinoma
 Fetal Death Antibodies  >3 publications with DHAND and Fetal Death
 Neural Tube Defects Antibodies  >3 publications with DHAND and Neural Tube Defects
 Central Nervous System Diseases Antibodies  >2 publications with DHAND and Central Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >146 publications with DHAND and Heart
 Embryonic Tissue Antibodies  >95 publications with DHAND and Embryonic Tissue
 Bone Antibodies  >54 publications with DHAND and Bone
 Nerve Antibodies  >29 publications with DHAND and Nerve
 Brain Antibodies  >11 publications with DHAND and Brain
 Uterus Antibodies  >7 publications with DHAND and Uterus
 Placenta Antibodies  >6 publications with DHAND and Placenta
 Adrenal Gland Antibodies  >5 publications with DHAND and Adrenal Gland
 Intestine Antibodies  >5 publications with DHAND and Intestine
 Mouth Antibodies  >4 publications with DHAND and Mouth
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