NP_068808.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,269 Da
NCBI Official Full Name
heart- and neural crest derivatives-expressed protein 2
NCBI Official Synonym Full Names
heart and neural crest derivatives expressed 2
NCBI Official Synonym Symbols
Hed; dHand; DHAND2; Thing2; bHLHa26 [Similar Products]
NCBI Protein Information
heart- and neural crest derivatives-expressed protein 2; class A basic helix-loop-helix protein 26; basic helix-loop-helix transcription factor HAND2; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
UniProt Protein Name
Heart- and neural crest derivatives-expressed protein 2
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 26; bHLHa26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND
UniProt Synonym Gene Names
UniProt Entry Name
HAND2_HUMAN
NCBI Summary for DHAND
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]
UniProt Comments for DHAND
HAND2: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 4q33
Cellular Component: transcription factor complex; protein complex; nuclear chromatin
Molecular Function: protein binding; protein homodimerization activity; transcription activator binding; AT DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding
Biological Process: adult heart development; heart morphogenesis; tongue development; neural crest cell development; thymus development; transcription, DNA-dependent; in utero embryonic development; apoptosis; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; heart development; mesenchymal cell proliferation; palate development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; peripheral nervous system neuron development; sympathetic nervous system development; regulation of transcription, DNA-dependent; suckling behavior; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast differentiation; angiogenesis; heart looping; embryonic digit morphogenesis
Research Articles on DHAND
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Products associated with anti-DHAND antibody
Pathways associated with anti-DHAND antibody
Diseases associated with anti-DHAND antibody
Organs/Tissues associated with anti-DHAND antibody
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