NP_000783.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 13 kDa; 29 kDa Predicted: 29 kDa
NCBI Official Full Name
type I iodothyronine deiodinase isoform a
NCBI Official Synonym Full Names
iodothyronine deiodinase 1
NCBI Official Synonym Symbols
NCBI Protein Information
type I iodothyronine deiodinase
UniProt Protein Name
Type I iodothyronine deiodinase
UniProt Synonym Protein Names
5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase
UniProt Synonym Gene Names
NCBI Summary for DIO1
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2018]
UniProt Comments for DIO1
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Research Articles on DIO1
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Pathways associated with anti-DIO1 antibody
Diseases associated with anti-DIO1 antibody
Organs/Tissues associated with anti-DIO1 antibody
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