Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Antibody rightarrow DISC1 rightarrow Polyclonal DISC1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • HA (H1N1)(A-South Carolina-1-18) Recombinant Protein
 • CYLD Antibody
 • CD11b Antibody
 • myeloperoxidase, MPO ELISA Kit
 • Klebsiella oxytoca Carbapenem-hydrolyzing beta-lactamase KPC... Recombinant Protein
 • Lipocalin 2 (LCN2) ELISA Kit
 • KIZ Antibody
 • Low-density lipoprotein receptor-related protein 1 (LRP1) Recombinant Protein
 • GRO-gamma (GRO g) Recombinant Protein
 • WAS-WASL interacting protein family, member 3 (WIPF3) ELISA Kit
 • Heat Shock Protein 90 (HSP90) ELISA Kit
 • 26S proteasome non-ATPase regulatory subunit 1 (Psmd1) Recombinant Protein
 • PGP9.5 (UCHL1) Antibody
 • Ezrin Antibody
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-DISC1 antibody :: Rabbit anti-Human, Mouse DISC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151155
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DISC1, Polyclonal Antibody

 Also Known As   

DISC1 Antibody

 Product Synonym Names    DISC1; SCZD9; C1orf136; KIAA0457; Disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1
 Product Gene Name   

anti-DISC1 antibody

[Similar Products]
 Antibody/Peptide Pairs    DISC1 peptide (MBS152422) is used for blocking the activity of DISC1 antibody (MBS151155)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    phenotype 605210
 3D Structure    ModBase 3D Structure for Q9NRI5
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
Section Bar
 Purity/Purification    DISC1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
Section Bar
 Conjugate    Unconjugated
 Immunogen    DISC1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human DISC1.
 Buffer    DISC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Section Bar
 Preparation and Storage    DISC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-DISC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar

Related Product Information for anti-DISC1 antibody

   DISC1 Antibody: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
 Applications Tested/Suitable for anti-DISC1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-DISC1 antibody    DISC1 antibody can be used for detection of DISC1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
Section Bar
 Western Blot (WB) of anti-DISC1 antibody    Western blot analysis of DISC1 in SK-N-SH cell lysate with DISC1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-DISC1 antibody Western Blot (WB) (WB) image
Section Bar
 Immunocytochemistry (ICC) of anti-DISC1 antibody    Immunocytochemistry of DISC1 in HeLa cells with DISC1 antibody at 5 μg/mL.
anti-DISC1 antibody Immunocytochemistry (ICC) (ICC) image
Section Bar
 Immunofluorescence (IF) of anti-DISC1 antibody    Immunofluorescence of DISC1 in Hela cells with DISC1 antibody at 20 μg/mL.
anti-DISC1 antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for DISC1. It may not necessarily be applicable to this product.
 NCBI GI #    61742823
 NCBI GeneID    27185
 NCBI Accession #    NP_061132 [Other Products]
 NCBI GenBank Nucleotide #    NM_018662.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9NRI5 [Other Products]
 UniProt Secondary Accession #    O75045; Q5VT44; A6NLH2; C4P091; C4P095; C4P0A1; C4P0A3; C4P0B3; C4P0B6; C4P0C1; C9J6D0 [Other Products]
 UniProt Related Accession #    Q9NRI5 [Other Products]
 Molecular Weight    22,198 Da
Table BarTOPTable Bar
 NCBI Official Full Name    disrupted in schizophrenia 1 protein isoform L
 NCBI Official Synonym Full Names    disrupted in schizophrenia 1
 NCBI Official Symbol    DISC1 [Similar Products]
 NCBI Official Synonym Symbols   
SCZD9; C1orf136
[Similar Products]
 NCBI Protein Information    disrupted in schizophrenia 1 protein
 UniProt Protein Name    Disrupted in schizophrenia 1 protein
 Protein Family    Disrupted in schizophrenia
 UniProt Gene Name    DISC1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0457 [Similar Products]
 UniProt Entry Name    DISC1_HUMAN
Section Bar
 NCBI Summary for DISC1    This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for DISC1    DISC1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: postsynaptic membrane; microtubule; centrosome; mitochondrion; postsynaptic density; cell junction

Molecular Function: protein binding

Biological Process: positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; TOR signaling pathway; cell proliferation in forebrain; neuron migration; cerebral cortex radially oriented cell migration; Wnt receptor signaling pathway through beta-catenin; microtubule cytoskeleton organization and biogenesis; positive regulation of Wnt receptor signaling pathway

Disease: Schizophrenia; Schizophrenia 9
Table BarTOPTable Bar
 Research Articles on DISC1    1. Results demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Diseases associated with anti-DISC1 antibodyOrgans/Tissues associated with anti-DISC1 antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >488 publications with DISC1 and Schizophrenia
 Cognition Disorders Antibodies  >27 publications with DISC1 and Cognition Disorders
 Learning Disorders Antibodies  >18 publications with DISC1 and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >17 publications with DISC1 and Neurobehavioral Manifestations
 Abnormalities, Multiple Antibodies  >12 publications with DISC1 and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >9 publications with DISC1 and Congenital Abnormalities
 Prenatal Exposure Delayed Effects Antibodies  >7 publications with DISC1 and Prenatal Exposure Delayed Effects
 Autistic Disorder Antibodies  >7 publications with DISC1 and Autistic Disorder
 Asperger Syndrome Antibodies  >5 publications with DISC1 and Asperger Syndrome
 Weight Loss Antibodies  >3 publications with DISC1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >398 publications with DISC1 and Nerve
 Brain Antibodies  >322 publications with DISC1 and Brain
 Embryonic Tissue Antibodies  >31 publications with DISC1 and Embryonic Tissue
 Blood Antibodies  >20 publications with DISC1 and Blood
 Muscle Antibodies  >8 publications with DISC1 and Muscle
 Kidney Antibodies  >5 publications with DISC1 and Kidney
 Heart Antibodies  >4 publications with DISC1 and Heart
 Lung Antibodies  >2 publications with DISC1 and Lung
 Bone Antibodies  >2 publications with DISC1 and Bone
 Ganglia Antibodies  >2 publications with DISC1 and Ganglia
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions