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anti-DKK1 antibody :: Goat DKK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421427
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DKK1, Polyclonal Antibody

 Also Known As   

Goat anti-DKK1 Antibody

 Product Synonym Names    DKK1; SK; DKK-1; dickkopf homolog 1 (Xenopus laevis); dickkopf-1 like; dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1; dickkopf related protein-1; DKK1 antibody; SK antibody; DKK-1 antibody; dickkopf homolog 1 (Xenopus laevis) antibody; dickkopf-1 like antibody; dickkopf (Xenopus laevis) homolog 1 antibody; dickkopf homolog 1 antibody; dickkopf related protein-1 antibody
 Product Gene Name   

anti-DKK1 antibody

[Similar Products]
 Antibody/Peptide Pairs    DKK1 peptide (MBS426796) is used for blocking the activity of DKK1 antibody (MBS421427)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    CDHHQASNSS RLHT
 OMIM    605189
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence CDHHQASNSSRLHT, from the C Terminus of the protein sequence according to NP_036374.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DKK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DKK1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-DKK1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 38kDa band observed in Human Spleen ysates (calculated MW of 28.7kDa according to NP_036374.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Fedi et al, J Biol Chem.1999 Jul 2;274(27): 19465-72; PMID: 10383463). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-DKK1 antibody    (1ug/ml) staining of human bone marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DKK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DKK1. It may not necessarily be applicable to this product.
 NCBI GI #    7110719
 NCBI GeneID    22943
 NCBI Accession #    NP_036374.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012242.2 [Other Products]
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 UniProt Secondary Accession #    B2RC19 [Other Products]
 UniProt Related Accession #    O94907 [Other Products]
 Molecular Weight    28,672 Da
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 NCBI Official Full Name    dickkopf-related protein 1
 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 1
 NCBI Official Symbol    DKK1 [Similar Products]
 NCBI Official Synonym Symbols   
SK; DKK-1
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 1
 UniProt Protein Name    Dickkopf-related protein 1
 UniProt Synonym Protein Names   
SK
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK1 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-1; Dkk-1; hDkk-1 [Similar Products]
 UniProt Entry Name    DKK1_HUMAN
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 NCBI Summary for DKK1    This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK1    DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: early endosome membrane; extracellular region; extracellular space; plasma membrane

Molecular Function: growth factor activity; low-density lipoprotein receptor binding; protein binding; receptor antagonist activity; signal transducer activity

Biological Process: cellular morphogenesis during differentiation; embryonic limb morphogenesis; endoderm formation; forebrain development; hair follicle development; mesoderm formation; negative regulation of BMP signaling pathway; negative regulation of mesodermal cell fate specification; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein binding; negative regulation of skeletal muscle development; negative regulation of synaptogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; regulation of endodermal cell fate specification; regulation of receptor internalization; regulation of synaptic transmission, glutamatergic; response to retinoic acid
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 Research Articles on DKK1    1. DKK1 can be regarded as a marker gene for the risk of tooth agenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DKK1 antibodyPathways associated with anti-DKK1 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >641 publications with DKK1 and CTNNB1
 WNT3A antibody  >150 publications with DKK1 and WNT3A
 LRP5 antibody  >134 publications with DKK1 and LRP5
 LRP6 antibody  >119 publications with DKK1 and LRP6
 MYC antibody  >66 publications with DKK1 and MYC
 WNT1 antibody  >49 publications with DKK1 and WNT1
 KREMEN1 antibody  >21 publications with DKK1 and KREMEN1
 KREMEN2 antibody  >15 publications with DKK1 and KREMEN2
 TP53 antibody  >12 publications with DKK1 and TP53
 TCF7L2 antibody  >6 publications with DKK1 and TCF7L2
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies  Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
Diseases associated with anti-DKK1 antibodyOrgans/Tissues associated with anti-DKK1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >102 publications with DKK1 and Cardiovascular Diseases
 Inflammation Antibodies  >64 publications with DKK1 and Inflammation
 Nervous System Diseases Antibodies  >49 publications with DKK1 and Nervous System Diseases
 Necrosis Antibodies  >45 publications with DKK1 and Necrosis
 Breast Neoplasms Antibodies  >45 publications with DKK1 and Breast Neoplasms
 Liver Diseases Antibodies  >44 publications with DKK1 and Liver Diseases
 Fractures, Bone Antibodies  >44 publications with DKK1 and Fractures, Bone
 Brain Diseases Antibodies  >43 publications with DKK1 and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >42 publications with DKK1 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >38 publications with DKK1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >569 publications with DKK1 and Bone
 Bone Marrow Antibodies  >113 publications with DKK1 and Bone Marrow
 Embryonic Tissue Antibodies  >107 publications with DKK1 and Embryonic Tissue
 Connective Tissue Antibodies  >93 publications with DKK1 and Connective Tissue
 Brain Antibodies  >87 publications with DKK1 and Brain
 Vascular Antibodies  >77 publications with DKK1 and Vascular
 Liver Antibodies  >63 publications with DKK1 and Liver
 Muscle Antibodies  >56 publications with DKK1 and Muscle
 Skin Antibodies  >55 publications with DKK1 and Skin
 Lung Antibodies  >52 publications with DKK1 and Lung
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