NP_001035951.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
disks large-associated protein 4 isoform c
NCBI Official Synonym Full Names
discs, large (Drosophila) homolog-associated protein 4
NCBI Official Synonym Symbols
DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4 [Similar Products]
NCBI Protein Information
disks large-associated protein 4
UniProt Protein Name
Disks large-associated protein 4
UniProt Synonym Protein Names
PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4
UniProt Synonym Gene Names
UniProt Entry Name
DLGP4_HUMAN
NCBI Summary for DLGAP4
The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DLGAP4
SAPAP4: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, peripheral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component: membrane; synapse
Molecular Function: protein binding
Biological Process: cell-cell signaling
Product References and Citations for anti-DLGAP4 antibody
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) : Rikova, K., et al. Cell 131(6):1190-1203(2007) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) Grelle, G., et al. Mol. Cell Proteomics 5(2):234-244(2006) Kawabe, H., et al. J. Biol. Chem. 274(43):30914-30918(1999)
Research Articles on DLGAP4
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Organs/Tissues associated with anti-DLGAP4 antibody
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