NP_005723.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
138,432 Da
NCBI Official Full Name
DNA repair protein RAD50
NCBI Official Synonym Full Names
RAD50 double strand break repair protein
NCBI Protein Information
DNA repair protein RAD50
UniProt Protein Name
DNA repair protein RAD50
UniProt Synonym Gene Names
NCBI Summary for RAD50
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
UniProt Comments for RAD50
RAD50: a component of the Mre11-Rad50-NBS1 (MRN) complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Three alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold; DNA repair, damage; EC 3.6.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: condensed nuclear chromosome; membrane; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm
Molecular Function: 3'-5' exonuclease activity; adenylate kinase activity; ATP-dependent DNA helicase activity; DNA binding; double-stranded telomeric DNA binding; G-quadruplex DNA binding; protein binding; protein binding, bridging; single-stranded DNA specific endodeoxyribonuclease activity; single-stranded telomeric DNA binding
Biological Process: DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; meiotic recombination; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of mitotic recombination; response to DNA damage stimulus; strand displacement; telomere maintenance; telomere maintenance via recombination; telomere maintenance via telomerase; telomeric 3' overhang formation
Disease: Nijmegen Breakage Syndrome-like Disorder
Research Articles on RAD50
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Products associated with anti-RAD50 antibody
Pathways associated with anti-RAD50 antibody
Diseases associated with anti-RAD50 antibody
Organs/Tissues associated with anti-RAD50 antibody
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