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anti-DNA ligase 1 antibody :: Rabbit anti-Human DNA ligase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005245
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA ligase 1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human DNA ligase 1 polyclonal Antibody

 Product Synonym Names    DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1; LIG1
 Product Gene Name   

anti-DNA ligase 1 antibody

[Similar Products]
 Product Synonym Gene Name    LIG1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126391
 3D Structure    ModBase 3D Structure for P18858
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human DNA ligase 1 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20222 / sc-20224 / sc-366180
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DNA ligase 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DNA ligase 1 antibody

   DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
 Product Categories/Family for anti-DNA ligase 1 antibody    Cell Cycle
 Applications Tested/Suitable for anti-DNA ligase 1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-DNA ligase 1 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-DNA ligase 1 antibody    Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7005245 at dilution 1:100
anti-DNA ligase 1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-DNA ligase 1 antibody    Immunofluorescent analysis of A549 cells using MBS7005245 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DNA ligase 1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for DNA ligase 1. It may not necessarily be applicable to this product.
 NCBI GI #    4557719
 NCBI GeneID    3978
 NCBI Accession #    NP_000225.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000234.2 [Other Products]
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 UniProt Primary Accession #    P18858 [Other Products]
 UniProt Secondary Accession #    Q2TB12; Q32P23; B2RAI8; B4DTU4 [Other Products]
 UniProt Related Accession #    P18858 [Other Products]
 Molecular Weight    98,228 Da
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 NCBI Official Full Name    DNA ligase 1 isoform 1
 NCBI Official Synonym Full Names    ligase I, DNA, ATP-dependent
 NCBI Official Symbol    LIG1 [Similar Products]
 NCBI Protein Information    DNA ligase 1
 UniProt Protein Name    DNA ligase 1
 UniProt Synonym Protein Names   
DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
 Protein Family    DNA ligase
 UniProt Gene Name    LIG1 [Similar Products]
 UniProt Entry Name    DNLI1_HUMAN
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 NCBI Summary for DNA ligase 1    This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for DNA ligase 1    LIG1: is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Protein type: Ligase; EC 6.5.1.1; DNA repair, damage

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus

Molecular Function: ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding

Biological Process: anatomical structure morphogenesis; base-excision repair; cell division; DNA ligation; DNA ligation during DNA repair; DNA metabolic process; DNA repair; DNA strand elongation during DNA replication; double-strand break repair via nonhomologous end joining; mismatch repair; mitotic cell cycle; nucleotide-excision repair; nucleotide-excision repair, DNA gap filling; response to hydrogen peroxide; telomere maintenance; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair; V(D)J recombination
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 Research Articles on DNA ligase 1    1. A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNA ligase 1 antibodyPathways associated with anti-DNA ligase 1 antibody
 Reference Product  PubMed Publications
 FEN1 antibody  >9 publications with DNA ligase 1 and FEN1
 PCNA antibody  >9 publications with DNA ligase 1 and PCNA
 APEX1 antibody  >5 publications with DNA ligase 1 and APEX1
 POLD1 antibody  >1 publications with DNA ligase 1 and POLD1
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-DNA ligase 1 antibodyOrgans/Tissues associated with anti-DNA ligase 1 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >9 publications with DNA ligase 1 and Lung Diseases
 Lung Neoplasms Antibodies  >9 publications with DNA ligase 1 and Lung Neoplasms
 Cognition Disorders Antibodies  >2 publications with DNA ligase 1 and Cognition Disorders
 Breast Neoplasms Antibodies  >2 publications with DNA ligase 1 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with DNA ligase 1 and Carcinoma, Squamous Cell
 Anemia Antibodies  >1 publications with DNA ligase 1 and Anemia
 Poisoning Antibodies  >1 publications with DNA ligase 1 and Poisoning
 Infertility, Female Antibodies  >1 publications with DNA ligase 1 and Infertility, Female
 Heart Diseases Antibodies  >1 publications with DNA ligase 1 and Heart Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with DNA ligase 1 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >15 publications with DNA ligase 1 and Lung
 Brain Antibodies  >9 publications with DNA ligase 1 and Brain
 Blood Antibodies  >6 publications with DNA ligase 1 and Blood
 Skin Antibodies  >3 publications with DNA ligase 1 and Skin
 Liver Antibodies  >3 publications with DNA ligase 1 and Liver
 Prostate Antibodies  >2 publications with DNA ligase 1 and Prostate
 Stomach Antibodies  >2 publications with DNA ligase 1 and Stomach
 Kidney Antibodies  >2 publications with DNA ligase 1 and Kidney
 Muscle Antibodies  >2 publications with DNA ligase 1 and Muscle
 Intestine Antibodies  >1 publications with DNA ligase 1 and Intestine
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