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anti-DNA antibody :: Rabbit anti-Human DNA polymerase gamma Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS837728
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA polymerase gamma, Polyclonal Antibody

 Also Known As   

DNA polymerase gamma antibody

 Product Synonym Names    Polyclonal DNA polymerase gamma; Anti-DNA polymerase gamma; PolG-alpha; FLJ27114; MIRAS; MTDPS4A; PEO; POLG1; SANDO; MTDPS4B; MDP1; mitochondrial DNA polymerase catalytic subunit; PolG catalytic subunit; POLG; POLGA; SCAE; DNA polymerase subunit gamma-1
 Product Gene Name   

anti-DNA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    157640
 3D Structure    ModBase 3D Structure for P54098
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    DNA polymerase gamma antibody was purified by antigen-affinity chromatography
 Form/Format    Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
 Concentration    0.67 mg/ml (lot specific)
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 Biological Significance    Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE).
 Immunogen    DNA polymerase gamma antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 779 and 1231 of DNA polymerase gamma
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-DNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DNA antibody

   Affinity purified Rabbit polyclonal DNA polymerase gamma antibody
 Product Categories/Family for anti-DNA antibody    Proteases, Inhibitors, & Enzymes; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-DNA antibody   

Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

 Application Notes for anti-DNA antibody    IF:1:100-1:500
ICC:1:100-1:500
IHC-P: 1:100-1:500
WB: 1:1000-1:10000
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 Western Blot (WB) of anti-DNA antibody    Western blot analysis of A. 50 ug Rat testis lysate/extract using a 5 % SDS PAGE gel and DNA polymerase gamma antibody at a dilution of 1:1000
anti-DNA antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-DNA antibody    Western blot analysis of 30 ug of whole cell lysate (A: MCF-7) using a 5 % SDS PAGE gel and DNA polymerase gamma antibody at a dilution of 1:1000
anti-DNA antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-DNA antibody    Immunofluorescence analysis of methanol-fixed HeLa, using DNA polymerase gamma antibody at 1:200 dilution.
anti-DNA antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-DNA antibody    Immunohistochemical staining of paraffin-embedded Skeletal Muscle using DNA polymerase gamma antibody
anti-DNA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DNA. It may not necessarily be applicable to this product.
 NCBI GI #    1399956
 NCBI GeneID    5428
 NCBI Accession #    AAC50712.1 [Other Products]
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 UniProt Primary Accession #    P54098 [Other Products]
 UniProt Secondary Accession #    Q8NFM2; Q92515 [Other Products]
 UniProt Related Accession #    P54098 [Other Products]
 Molecular Weight    140 kDa
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 NCBI Official Full Name    DNA polymerase gamma
 NCBI Official Synonym Full Names    polymerase (DNA directed), gamma
 NCBI Official Symbol    POLG [Similar Products]
 NCBI Official Synonym Symbols   
PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B
[Similar Products]
 NCBI Protein Information    DNA polymerase subunit gamma-1
 UniProt Protein Name    DNA polymerase subunit gamma-1
 UniProt Synonym Protein Names   
Mitochondrial DNA polymerase catalytic subunit; PolG-alpha
 Protein Family    DNA polymerase
 UniProt Gene Name    POLG [Similar Products]
 UniProt Synonym Gene Names    MDP1; POLG1; POLGA [Similar Products]
 UniProt Entry Name    DPOG1_HUMAN
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 NCBI Summary for DNA    Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DNA    POLG: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA. Defects in POLG are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 1 (PEOA1). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Defects in POLG are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal recessive (PEOB). PEOB is a severe form of progressive external ophthalmoplegia. It is clinically more heterogeneous than the autosomal dominant forms. Can be more severe. Defects in POLG are a cause of sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO). SANDO is a systemic disorder resulting from mitochondrial dysfunction associated with mitochondrial depletion in skeletal muscle and peripheral nerve tissue. The clinical triad of symptoms consists of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. However, the phenotype varies widely, even within the same family, and can also include myopathy, seizures, and hearing loss. An atypical form of the disease is characterized by headaches and/or seizures manifesting in childhood or adolescence, followed by development of cerebellar and sensory ataxia, dysarthria, progressive external ophthalmoplegia, and myoclonus in early adulthood. Defects in POLG are the cause of mitochondrial DNA depletion syndrome type 4A (MTDPS4A); also called Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis. An autosomal recessive hepatocerebral syndrome. The typical course of the disease includes severe developmental delay, intractable seizures, liver failure, and death in childhood. Refractory seizures, cortical blindness, progressive liver dysfunction, and acute liver failure after exposure to valproic acid are considered diagnostic features. The neuropathological hallmarks are neuronal loss, spongiform degeneration, and astrocytosis of the visual cortex. Liver biopsy results show steatosis, often progressing to cirrhosis. Defects in POLG are the cause of mitochondrial DNA depletion syndrome type 4B (MTDPS4B); also known as mitochondrial DNA depletion syndrome 4B MNGIE type or mitochondrial neurogastrointestinal encephalopathy syndrome POLG- related. An autosomal recessive progressive multisystem disorder clinically characterized by chronic gastrointestinal dysmotility and pseudo-obstruction, cachexia, progressive external ophthalmoplegia, axonal sensory ataxic neuropathy, and muscle weakness. Defects in POLG are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Belongs to the DNA polymerase type-A family.

Protein type: DNA repair, damage; EC 2.7.7.7; Mitochondrial; DNA replication; Transferase

Chromosomal Location of Human Ortholog: 15q25

Cellular Component: gamma DNA polymerase complex; mitochondrion; mitochondrial inner membrane

Molecular Function: protein binding; protease binding; DNA binding; exonuclease activity; DNA-directed DNA polymerase activity; chromatin binding

Biological Process: base-excision repair, gap-filling; mitochondrial DNA replication; DNA-dependent DNA replication; DNA metabolic process; aging

Disease: Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis; Mitochondrial Dna Depletion Syndrome 1 (mngie Type); Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 1; Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive; Mitochondrial Dna Depletion Syndrome 4b (mngie Type); Mitochondrial Dna Depletion Syndrome 4a (alpers Type)
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 Research Articles on DNA    1. A POLG gene mutation was identified in a case of hypertrophic olivary degeneration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNA antibodyPathways associated with anti-DNA antibody
 Reference Product  PubMed Publications
 C10orf2 antibody  >53 publications with DNA and C10orf2
 POLG2 antibody  >31 publications with DNA and POLG2
 MPV17 antibody  >22 publications with DNA and MPV17
 TFAM antibody  >22 publications with DNA and TFAM
 TK2 antibody  >19 publications with DNA and TK2
 DGUOK antibody  >17 publications with DNA and DGUOK
 TYMP antibody  >11 publications with DNA and TYMP
 SLC25A4 antibody  >4 publications with DNA and SLC25A4
 POLD1 antibody  >1 publications with DNA and POLD1
 Products by Pathway  Pathway Diagram
 DNA Polymerase Gamma Complex Pathway antibodies  DNA Polymerase Gamma Complex Pathway Diagram
 DNA Polymerase Gamma Complex Pathway antibodies  DNA Polymerase Gamma Complex Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
Diseases associated with anti-DNA antibodyOrgans/Tissues associated with anti-DNA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >270 publications with DNA and Nervous System Diseases
 Mitochondrial Diseases Antibodies  >238 publications with DNA and Mitochondrial Diseases
 Brain Diseases Antibodies  >183 publications with DNA and Brain Diseases
 Epilepsy Antibodies  >83 publications with DNA and Epilepsy
 Ophthalmoplegia, Chronic Progressive External Antibodies  >67 publications with DNA and Ophthalmoplegia, Chronic Progressive External
 Diffuse Cerebral Sclerosis of Schilder Antibodies  >58 publications with DNA and Diffuse Cerebral Sclerosis of Schilder
 Liver Diseases Antibodies  >51 publications with DNA and Liver Diseases
 Seizures Antibodies  >48 publications with DNA and Seizures
 Parkinsonian Disorders Antibodies  >38 publications with DNA and Parkinsonian Disorders
 Peripheral Nervous System Diseases Antibodies  >33 publications with DNA and Peripheral Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >137 publications with DNA and Muscle
 Brain Antibodies  >110 publications with DNA and Brain
 Liver Antibodies  >79 publications with DNA and Liver
 Blood Antibodies  >30 publications with DNA and Blood
 Eye Antibodies  >12 publications with DNA and Eye
 Skin Antibodies  >8 publications with DNA and Skin
 Spinal Cord Antibodies  >7 publications with DNA and Spinal Cord
 Kidney Antibodies  >5 publications with DNA and Kidney
 Vascular Antibodies  >5 publications with DNA and Vascular
 Bone Antibodies  >4 publications with DNA and Bone
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