NP_001362.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Synonym Full Names
dynein axonemal heavy chain 8
NCBI Protein Information
dynein heavy chain 8, axonemal
UniProt Protein Name
Dynein heavy chain 8, axonemal
UniProt Synonym Protein Names
Axonemal beta dynein heavy chain 8; Ciliary dynein heavy chain 8
UniProt Entry Name
DYH8_HUMAN
NCBI Summary for DNAH8
The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
UniProt Comments for DNAH8
DNAH8: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 6p21.2
Cellular Component: axonemal dynein complex; cytoplasm; dynein complex; microtubule
Molecular Function: ATP binding; ATPase activity; microtubule motor activity
Biological Process: ciliary or flagellar motility; metabolic process; microtubule-based movement
Research Articles on DNAH8
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Pathways associated with anti-DNAH8 antibody
Diseases associated with anti-DNAH8 antibody
Organs/Tissues associated with anti-DNAH8 antibody
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