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anti-DNAJC19 antibody :: Rabbit anti-Human, Mouse DNAJC19 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044335
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNAJC19, Polyclonal Antibody

★Popular Item★
 Also Known As   

DNAJC19 Antibody

 Product Synonym Names    Mitochondrial import inner membrane translocase subunit TIM14; DnaJ homolog subfamily C member 19; DNAJC19; TIM14; TIMM14
 Product Gene Name   

anti-DNAJC19 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608977
 3D Structure    ModBase 3D Structure for Q96DA6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Mitochondrial import inner membrane translocase subunit TIM14 protein (1-116AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DNAJC19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DNAJC19 antibody

   Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
 Applications Tested/Suitable for anti-DNAJC19 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-DNAJC19 antibody    Western blot
All lanes: DNAJC19 antibody at 0.9 ug/ml
Lane 1: Mouse lung tissue
Lane 2: Mouse kidney tissue
Lane 3: A549 whole cell lysate
Lane 4: HL60 whole cell lysate
Lane 5: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 13,11 kDa
Observed band size: 12 kDa

anti-DNAJC19 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-DNAJC19 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7044335 at dilution of 1:100
anti-DNAJC19 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DNAJC19 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7044335 at dilution of 1:100
anti-DNAJC19 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DNAJC19. It may not necessarily be applicable to this product.
 NCBI GI #    298231213
 NCBI GeneID    131118
 NCBI Accession #    NP_001177162.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190233.1 [Other Products]
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 UniProt Primary Accession #    Q96DA6 [Other Products]
 UniProt Secondary Accession #    B2R4B1; C9JBV1 [Other Products]
 UniProt Related Accession #    Q96DA6 [Other Products]
 Molecular Weight    10,079 Da
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 NCBI Official Full Name    mitochondrial import inner membrane translocase subunit TIM14 isoform 2
 NCBI Official Synonym Full Names    DnaJ heat shock protein family (Hsp40) member C19
 NCBI Official Symbol    DNAJC19 [Similar Products]
 NCBI Official Synonym Symbols   
PAM18; TIM14; TIMM14
[Similar Products]
 NCBI Protein Information    mitochondrial import inner membrane translocase subunit TIM14
 UniProt Protein Name    Mitochondrial import inner membrane translocase subunit TIM14
 UniProt Synonym Protein Names   
DnaJ homolog subfamily C member 19
 UniProt Gene Name    DNAJC19 [Similar Products]
 UniProt Synonym Gene Names    TIM14; TIMM14 [Similar Products]
 UniProt Entry Name    TIM14_HUMAN
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 NCBI Summary for DNAJC19    The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012]
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 UniProt Comments for DNAJC19    DNAJC19: Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity. Defects in DNAJC19 are the cause of 3-methylglutaconic aciduria type 5 (MGA5); also known as dilated cardiomyopathy with ataxia (DCMA). MGA5 is an autosomal recessive disorder characterized by early-onset dilated cardiomyopathy, growth failure, cerebellar ataxia causing significant motor delays, testicular dysgenesis, growth failure, and significant increases in urine organic acids, particularly 3-methylglutaconic acid and 3-methylglutaric acid. Belongs to the TIM14 family.

Protein type: Membrane protein, integral; Chaperone; Mitochondrial

Chromosomal Location of Human Ortholog: 3q26.33

Cellular Component: mitochondrial inner membrane; mitochondrion; protein complex

Molecular Function: protein binding

Biological Process: genitalia development; visual perception

Disease: 3-methylglutaconic Aciduria, Type V
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 Research Articles on DNAJC19    1. The loss of DNAJC19/PHB complexes affects cardiolipin acylation and leads to the accumulation of cardiolipin species with altered acyl chains.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DNAJC19 antibodyDiseases associated with anti-DNAJC19 antibody
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 Disease Name  Pubmed Publications
 Ataxia Antibodies  >7 publications with DNAJC19 and Ataxia
 Heart Diseases Antibodies  >6 publications with DNAJC19 and Heart Diseases
 Abnormalities, Multiple Antibodies  >3 publications with DNAJC19 and Abnormalities, Multiple
 Nervous System Diseases Antibodies  >3 publications with DNAJC19 and Nervous System Diseases
 Heart Defects, Congenital Antibodies  >1 publications with DNAJC19 and Heart Defects, Congenital
 3-Methylglutaconic Aciduria, Type V Antibodies  >1 publications with DNAJC19 and 3-Methylglutaconic Aciduria, Type V
Organs/Tissues associated with anti-DNAJC19 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with DNAJC19 and Eye
 Liver Antibodies  >1 publications with DNAJC19 and Liver
 Prostate Antibodies  >1 publications with DNAJC19 and Prostate
 Brain Antibodies  >1 publications with DNAJC19 and Brain
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