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anti-DNAJC2 antibody :: Rabbit DNAJC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9213732
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNAJC2, Polyclonal Antibody

★Popular Item★
 Also Known As   

DNAJC2 Antibody (Center)

 Product Synonym Names    DnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; Zuotin-related factor 1; DnaJ homolog subfamily C member 2; N-terminally processed; DNAJC2; MPHOSPH11; MPP11; ZRF1
 Product Gene Name   

anti-DNAJC2 antibody

[Similar Products]
 Antibody/Peptide Pairs    DNAJC2 peptide (MBS9228459) is used for blocking the activity of DNAJC2 antibody (MBS9213732)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    226-255
 OMIM    605502
 3D Structure    ModBase 3D Structure for Q99543
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Bovine, Monkey)
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 Specificity    This DNAJC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-255 amino acids from the Central region of human DNAJC2.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Primary Accession    Q99543
 Other Accession    Q4R8H2, Q1RMH9
 Precautions    DNAJC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
 Cellular Location    Nucleus. Cytoplasm, cytosol.
 Tissue Location    Widely expressed.
 Clone Name    RB24170
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-DNAJC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DNAJC2 antibody

   This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6.

Function:
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
 Product Categories/Family for anti-DNAJC2 antibody    Cancer; Signal Transduction
 Applications Tested/Suitable for anti-DNAJC2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-DNAJC2 antibody    WB~~1:1000
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 Western Blot (WB) of anti-DNAJC2 antibody    Western blot analysis of DNAJC2 Antibody (Center) in mouse Neuro-2a cell line lysates (35ug/lane). DNAJC2 (arrow) was detected using the purified Pab.
anti-DNAJC2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DNAJC2. It may not necessarily be applicable to this product.
 NCBI GI #    193788632
 NCBI GeneID    27000
 NCBI Accession #    NP_001123359.1 [Other Products]
 NCBI Related Accession #    NP_055192.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001129887.1 [Other Products]
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 UniProt Primary Accession #    Q99543 [Other Products]
 UniProt Secondary Accession #    Q9BVX1; A4VCI0 [Other Products]
 UniProt Related Accession #    Q99543 [Other Products]
 Molecular Weight    71996
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 NCBI Official Full Name    dnaJ homolog subfamily C member 2 isoform 2
 NCBI Official Synonym Full Names    DnaJ (Hsp40) homolog, subfamily C, member 2
 NCBI Official Symbol    DNAJC2 [Similar Products]
 NCBI Official Synonym Symbols   
ZRF1; ZUO1; MPP11; MPHOSPH11
[Similar Products]
 NCBI Protein Information    dnaJ homolog subfamily C member 2
 UniProt Protein Name    DnaJ homolog subfamily C member 2
 UniProt Synonym Protein Names   
M-phase phosphoprotein 11; Zuotin-related factor 1
 Protein Family    DnaJ homolog subfamily
 UniProt Gene Name    DNAJC2 [Similar Products]
 UniProt Synonym Gene Names    MPHOSPH11; MPP11; ZRF1 [Similar Products]
 UniProt Entry Name    DNJC2_HUMAN
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 NCBI Summary for DNAJC2    This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DNAJC2    DNAJC2: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA replication; Chaperone

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: nuclear membrane; cytoplasm; nucleus; cytosol

Molecular Function: ubiquitin binding; DNA binding; histone binding; chromatin binding; Hsp70 protein binding

Biological Process: 'de novo' cotranslational protein folding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; chromatin modification; negative regulation of cell growth; DNA replication
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Product References and Citations for anti-DNAJC2 antibody

   Hatzold, J., et al. PLoS Biol. 6 (4), E84 (2008) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Otto, H., et al. Proc. Natl. Acad. Sci. U.S.A. 102(29):10064-10069(2005)
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 Research Articles on DNAJC2    1. our data reveal that ZRF1 is a key transcriptional regulator in leukemia progression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNAJC2 antibodyDiseases associated with anti-DNAJC2 antibody
 Reference Product  PubMed Publications
 HSPA8 antibody  >1 publications with DNAJC2 and HSPA8
 DNAJC21 antibody  >1 publications with DNAJC2 and DNAJC21
 Disease Name  Pubmed Publications
 Poisoning Antibodies  >1 publications with DNAJC2 and Poisoning
 Kidney Neoplasms Antibodies  >1 publications with DNAJC2 and Kidney Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with DNAJC2 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >1 publications with DNAJC2 and Kidney Diseases
Organs/Tissues associated with anti-DNAJC2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with DNAJC2 and Blood
 Eye Antibodies  >1 publications with DNAJC2 and Eye
 Skin Antibodies  >1 publications with DNAJC2 and Skin
 Kidney Antibodies  >1 publications with DNAJC2 and Kidney
 Liver Antibodies  >1 publications with DNAJC2 and Liver
 Testis Antibodies  >1 publications with DNAJC2 and Testis
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