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anti-DNAJC5 antibody :: Rabbit DNAJC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9605467
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNAJC5, Polyclonal Antibody

★Popular Item★
 Also Known As   

DNAJC5 Antibody

 Product Synonym Names    CLN 4; CLN4; CLN4B; CSP; cysteine string protein alpha; Cysteine string protein; DJC5; DnaJ (Hsp40) homolog subfamily C member 5; DnaJ homolog subfamily C member 5; DNAJC 5; Dnajc5; DNAJC5A; DNJC5_HUMAN; NCL
 Product Gene Name   

anti-DNAJC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9H3Z4
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    DNAJC5 antibody detects endogenous levels of total DNAJC5
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
 Tissue Specificity    Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-DNAJC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DNAJC5 antibody

   Function: Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).
Subunit Structure: Oligomers (PubMed:27452402). Homodimer (By similarity). Interacts with the chaperone complex consisting of HSC70 and SGTA (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895). Interacts with SYT1, SYT5 and SYT7, and with SYT9, forming a complex with SNAP25 (By similarity).
Post-translational Modifications: Fatty acylated (By similarity). Heavily palmitoylated in the cysteine string motif (By similarity). Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (PubMed:27452402). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (PubMed:27452402).
 Applications Tested/Suitable for anti-DNAJC5 antibody   

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-DNAJC5 antibody    WB: 1:500-1:1000
IF/ICC: 1:100-1:500
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 Western Blot (WB) of anti-DNAJC5 antibody    Western blot analysis of extracts from Jurkat using DNAJC5 antibody.
anti-DNAJC5 antibody Western Blot (WB) (WB) image
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 Immunofluorescene (IF) of anti-DNAJC5 antibody    MBS9605467 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-DNAJC5 antibody Immunofluorescene (IF) image
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NCBI/Uniprot data below describe general gene information for DNAJC5. It may not necessarily be applicable to this product.
 NCBI GI #    45504382
 NCBI GeneID    80331
 NCBI Accession #    NP_079495.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_025219.2 [Other Products]
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 UniProt Primary Accession #    Q9H3Z4 [Other Products]
 UniProt Secondary Accession #    Q9H3Z5; Q9H7H2; A8K0M0; B3KY68; E1P5G8 [Other Products]
 UniProt Related Accession #    Q9H3Z4 [Other Products]
 Molecular Weight    Observed: 30 kD
Predicted: 23 kDa
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 NCBI Official Full Name    dnaJ homolog subfamily C member 5
 NCBI Official Synonym Full Names    DnaJ heat shock protein family (Hsp40) member C5
 NCBI Official Symbol    DNAJC5 [Similar Products]
 NCBI Official Synonym Symbols   
CSP; NCL; CLN4; CLN4B; DNAJC5A; mir-941-2; mir-941-3; mir-941-4; mir-941-5
[Similar Products]
 NCBI Protein Information    dnaJ homolog subfamily C member 5
 UniProt Protein Name    DnaJ homolog subfamily C member 5
 UniProt Synonym Protein Names   
Ceroid-lipofuscinosis neuronal protein 4
 Protein Family    DnaJ homolog subfamily
 UniProt Gene Name    DNAJC5 [Similar Products]
 UniProt Synonym Gene Names    CSP1 PublicationManual assertion based on opinion iniRef.1 [Similar Products]
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 NCBI Summary for DNAJC5    This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
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 UniProt Comments for DNAJC5    Acts as a general chaperone in regulated exocytosis (). Acts as a co-chaperone for the SNARE protein SNAP-25 (). Involved in the calcium-mediated control of a late stage of exocytosis (). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings ().
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 Research Articles on DNAJC5    1. Results indicate that by assisting local lysosome/proteasome processes, CSPalpha-mediated removal of toxic proteins via extracellular vesicles plays a central role in synaptic proteostasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DNAJC5 antibodyDiseases associated with anti-DNAJC5 antibody
 Products by Pathway  Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with DNAJC5 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with DNAJC5 and Brain Diseases
 Seizures Antibodies  >2 publications with DNAJC5 and Seizures
 Central Nervous System Diseases Antibodies  >1 publications with DNAJC5 and Central Nervous System Diseases
 Epilepsy, Tonic-Clonic Antibodies  >1 publications with DNAJC5 and Epilepsy, Tonic-Clonic
 Cognition Disorders Antibodies  >1 publications with DNAJC5 and Cognition Disorders
Organs/Tissues associated with anti-DNAJC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with DNAJC5 and Brain
 Nerve Antibodies  >2 publications with DNAJC5 and Nerve
 Muscle Antibodies  >1 publications with DNAJC5 and Muscle
 Skin Antibodies  >1 publications with DNAJC5 and Skin
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