AAC50560.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 39 Observed MW: 38
NCBI Official Full Name
DNAM-1
NCBI Official Synonym Full Names
CD226 molecule
NCBI Protein Information
CD226 antigen
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1; DNAM-1; CD_antigen: CD226
UniProt Synonym Gene Names
UniProt Entry Name
CD226_HUMAN
NCBI Summary for DNAM-1
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Comments for DNAM-1
DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q22.3
Cellular Component: cell surface; cell-cell adherens junction; external side of plasma membrane; integral to plasma membrane; lipid raft; plasma membrane
Molecular Function: cell adhesion molecule binding; integrin binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity
Biological Process: cell adhesion; cell recognition; cytokine production; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of immune response; signal transduction
Research Articles on DNAM-1
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Products associated with anti-DNAM-1 antibody
Pathways associated with anti-DNAM-1 antibody
Diseases associated with anti-DNAM-1 antibody
Organs/Tissues associated with anti-DNAM-1 antibody
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