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anti-DNMT antibody :: Chicken anti-Human DNMT / DNMT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242266
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNMT / DNMT1, Polyclonal Antibody

 Also Known As   

Chicken Polyclonal (IgY) to Human DNMT / DNMT1

 Product Synonym Names    Anti-DNMT / DNMT1 Antibody (aa177-550) IHC-plus; DNMT1; AIM; CXXC finger protein 9; CXXC9; DNA methyltransferase 1; DNMT; DNA methyltransferase HsaI; DNA MTase HsaI; HSN1E; M.HsaI; MCMT; Human DNMT; DNMT1
 Product Gene Name   

anti-DNMT antibody

[Similar Products]
 Product Synonym Gene Name    DNMT1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 614116
 3D Structure    ModBase 3D Structure for P26358
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 Clonality    Polyclonal
 Isotype    IgY
 Host    Chicken
 Species Reactivity    Human
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 Specificity    Amino acids 177-550 human DNMT1
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS. No preservative added.
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 Target Species    Human
 Immunogen Description    Recombinant human DNMT1.
 Immunogen Type    Recombinant protein
 Immunogen    DNMT / DNMT1 antibody was raised against recombinant human DNMT1.
 Antigen Modification    aa177-550
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-DNMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DNMT antibody

   DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.
 Product Categories/Family for anti-DNMT antibody    Family: C5-methyltransferase
 Applications Tested/Suitable for anti-DNMT antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-DNMT antibody    IHC-P (2.5 ug/ml), WB (1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-DNMT antibody    Anti-DNMT1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-DNMT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DNMT antibody    Anti-DNMT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-DNMT antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DNMT. It may not necessarily be applicable to this product.
 NCBI GI #    4503351
 NCBI GeneID    1786
 NCBI Accession #    NP_001370.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001379.2 [Other Products]
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 UniProt Primary Accession #    P26358 [Other Products]
 UniProt Secondary Accession #    Q9UHG5; Q9ULA2; Q9UMZ6; A0AV63; B7ZLW6 [Other Products]
 UniProt Related Accession #    P26358 [Other Products]
 Molecular Weight    144,465 Da
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 NCBI Official Full Name    DNA (cytosine-5)-methyltransferase 1 isoform b
 NCBI Official Synonym Full Names    DNA (cytosine-5-)-methyltransferase 1
 NCBI Official Symbol    DNMT1 [Similar Products]
 NCBI Official Synonym Symbols   
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN
[Similar Products]
 NCBI Protein Information    DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; m.HsaI; DNA MTase HsaI; DNA methyltransferase HsaI; CXXC-type zinc finger protein 9
 UniProt Protein Name    DNA (cytosine-5)-methyltransferase 1
 UniProt Synonym Protein Names   
CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMT
 Protein Family    DNA
 UniProt Gene Name    DNMT1 [Similar Products]
 UniProt Synonym Gene Names    AIM; CXXC9; DNMT; Dnmt1; DNA MTase HsaI; M.HsaI [Similar Products]
 UniProt Entry Name    DNMT1_HUMAN
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 NCBI Summary for DNMT    DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for DNMT    DNMT1: an ubiquitous DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development, and may play an active role in DNA damage repair. Mediates transcriptional repression by direct binding to HDAC2. Its abundance is reduced to non detectable levels at the G0 phase of the cell cycle and is dramatically induced upon entrance into the S-phase of the cell cycle. Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Three isoforms of the human protein produced by alternative splicing have been described.

Protein type: Methyltransferase; Methyltransferase, DNA; EC 2.1.1.37; Cell development/differentiation; Transcription regulation; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleoplasm; centric heterochromatin; replication fork; nucleus

Molecular Function: DNA (cytosine-5-)-methyltransferase activity; protein binding; DNA binding; methyl-CpG binding; zinc ion binding; RNA binding; chromatin binding; transcription factor binding; DNA-methyltransferase activity

Biological Process: negative regulation of histone H3-K9 methylation; transcription, DNA-dependent; maintenance of DNA methylation; negative regulation of gene expression, epigenetic; DNA methylation; gene expression; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; gene silencing; chromatin modification; DNA methylation on cytosine; regulation of gene expression, epigenetic; regulation of cell proliferation

Disease: Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant; Neuropathy, Hereditary Sensory, Type Ie
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 Research Articles on DNMT    1. These findings strongly support the autoinhibitory role of the RFTS domain, and indicate that it contributes to the regulation of Dnmt1 activity in cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNMT antibodyPathways associated with anti-DNMT antibody
 Reference Product  PubMed Publications
 DNMT3B antibody  >505 publications with DNMT and DNMT3B
 MECP2 antibody  >100 publications with DNMT and MECP2
 HDAC1 antibody  >99 publications with DNMT and HDAC1
 UHRF1 antibody  >67 publications with DNMT and UHRF1
 PCNA antibody  >65 publications with DNMT and PCNA
 DMAP1 antibody  >63 publications with DNMT and DMAP1
 SUV39H1 antibody  >30 publications with DNMT and SUV39H1
 RB1 antibody  >7 publications with DNMT and RB1
 USP7 antibody  >6 publications with DNMT and USP7
 Products by Pathway  Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 DNA Methylation Pathway antibodies  DNA Methylation Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
Diseases associated with anti-DNMT antibodyOrgans/Tissues associated with anti-DNMT antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >217 publications with DNMT and Carcinoma
 Adenocarcinoma Antibodies  >100 publications with DNMT and Adenocarcinoma
 Breast Neoplasms Antibodies  >87 publications with DNMT and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >60 publications with DNMT and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >58 publications with DNMT and Disease Models, Animal
 Liver Diseases Antibodies  >58 publications with DNMT and Liver Diseases
 Lung Neoplasms Antibodies  >56 publications with DNMT and Lung Neoplasms
 Liver Neoplasms Antibodies  >51 publications with DNMT and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >50 publications with DNMT and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >40 publications with DNMT and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >171 publications with DNMT and Blood
 Brain Antibodies  >128 publications with DNMT and Brain
 Liver Antibodies  >115 publications with DNMT and Liver
 Lung Antibodies  >95 publications with DNMT and Lung
 Embryonic Tissue Antibodies  >47 publications with DNMT and Embryonic Tissue
 Prostate Antibodies  >46 publications with DNMT and Prostate
 Stomach Antibodies  >39 publications with DNMT and Stomach
 Nerve Antibodies  >34 publications with DNMT and Nerve
 Muscle Antibodies  >33 publications with DNMT and Muscle
 Skin Antibodies  >33 publications with DNMT and Skin
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