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anti-DNMT3A antibody :: Rabbit DNMT3A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS416641
Testing Data
Unit / Price
0.1 mL  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNMT3A, Polyclonal Antibody

 Also Known As   

Anti-DNMT3A Antibody

 Product Gene Name   

anti-DNMT3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602769
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human. Predicted: Mouse, Rat.
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 Purity/Purification    Affinity purified
 Form/Format    Liquid
 Concentration    100ug/100ul (lot specific)
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 Storage Buffer    PBS, pH 7.4 with 0.02% Sodium Azide
 Immunogen    Rabbit polyclonal DNMT3A (1) antibody was raised against a recombinate human DNMT3A protein 711-912aa (BC043617).
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 Preparation and Storage    This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
 Other Notes    Small volumes of anti-DNMT3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DNMT3A antibody

   CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
 Applications Tested/Suitable for anti-DNMT3A antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-DNMT3A antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Optimal dilutions/concentrations should be determined by the end user
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 Testing Data of anti-DNMT3A antibody    anti-DNMT3A antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for DNMT3A. It may not necessarily be applicable to this product.
 NCBI GI #    77176455
 NCBI GeneID    1788
 NCBI Accession #    NP_715640.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_153759.3 [Other Products]
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 UniProt Secondary Accession #    Q86TE8; Q86XF5; Q8IZV0; Q8WXU9; E9PEB8 [Other Products]
 UniProt Related Accession #    Q9Y6K1 [Other Products]
 Molecular Weight    16,866 Da
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 NCBI Official Full Name    DNA (cytosine-5)-methyltransferase 3A isoform b
 NCBI Official Synonym Full Names    DNA (cytosine-5-)-methyltransferase 3 alpha
 NCBI Official Symbol    DNMT3A [Similar Products]
 NCBI Official Synonym Symbols   
TBRS; DNMT3A2; M.HsaIIIA
[Similar Products]
 NCBI Protein Information    DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2
 UniProt Protein Name    DNA (cytosine-5)-methyltransferase 3A
 UniProt Synonym Protein Names   
DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA
 Protein Family    DNA
 UniProt Gene Name    DNMT3A [Similar Products]
 UniProt Entry Name    DNM3A_HUMAN
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 NCBI Summary for DNMT3A    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DNMT3A    DNMT3A: a DNA methyltransferase required for genome wide de novo methylation and essential for development. DNA methylation is coordinated with methylation of histones. Prefers CpG methylation to CpA, CpT, and CpC methylation. Methylates CpG sites at a rate much slower than DNMT1, but greater than DNMT3b. Methylation is coordinated with methylation of histones. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1 and DNMT1. Can co-localize with heterochromatin protein (HP1 ) and methyl-CpG binding protein (MeCBP). Associates with HDAC1 through its ADD-type zinc-finger. Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.

Protein type: Amino Acid Metabolism - cysteine and methionine; Methyltransferase; EC 2.1.1.37; Methyltransferase, DNA

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: XY body; nucleoplasm; euchromatin; nuclear matrix; cytoplasm; nuclear heterochromatin; nucleus; chromosome, pericentric region

Molecular Function: DNA (cytosine-5-)-methyltransferase activity; identical protein binding; protein binding; DNA binding; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; unmethylated CpG binding; metal ion binding; chromatin binding; DNA-methyltransferase activity

Biological Process: establishment and/or maintenance of chromatin architecture; genetic imprinting; DNA methylation during gametogenesis; S-adenosylhomocysteine metabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; cytosine methylation within a CG sequence; methylation-dependent chromatin silencing; negative regulation of gene expression, epigenetic; DNA methylation; S-adenosylmethioninamine metabolic process; spermatogenesis; gene expression; DNA methylation during embryonic development; DNA methylation on cytosine

Disease: Tatton-brown-rahman Syndrome
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Product References and Citations for anti-DNMT3A antibody

   (1) Liu,D., Zhou,P., Zhang,L. et al. Differential expression of Oct4 in HPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A. Tumour Biol. 32 (5), 941-950 (2011).
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 Research Articles on DNMT3A    1. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNMT3A antibodyPathways associated with anti-DNMT3A antibody
 Reference Product  PubMed Publications
 DNMT3B antibody  >533 publications with DNMT3A and DNMT3B
 DNMT1 antibody  >529 publications with DNMT3A and DNMT1
 DNMT3L antibody  >118 publications with DNMT3A and DNMT3L
 EZH2 antibody  >61 publications with DNMT3A and EZH2
 MYC antibody  >19 publications with DNMT3A and MYC
 SUV39H1 antibody  >14 publications with DNMT3A and SUV39H1
 UHRF1 antibody  >12 publications with DNMT3A and UHRF1
 SETDB1 antibody  >7 publications with DNMT3A and SETDB1
 CBX5 antibody  >1 publications with DNMT3A and CBX5
 ZBTB17 antibody  >1 publications with DNMT3A and ZBTB17
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 DNA Methylation Pathway antibodies  DNA Methylation Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
Diseases associated with anti-DNMT3A antibodyOrgans/Tissues associated with anti-DNMT3A antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >36 publications with DNMT3A and Disease Models, Animal
 Adenocarcinoma Antibodies  >35 publications with DNMT3A and Adenocarcinoma
 Breast Neoplasms Antibodies  >31 publications with DNMT3A and Breast Neoplasms
 Liver Diseases Antibodies  >28 publications with DNMT3A and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >24 publications with DNMT3A and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >21 publications with DNMT3A and Lung Neoplasms
 Liver Neoplasms Antibodies  >21 publications with DNMT3A and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >17 publications with DNMT3A and Cardiovascular Diseases
 Ovarian Neoplasms Antibodies  >16 publications with DNMT3A and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >16 publications with DNMT3A and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >152 publications with DNMT3A and Blood
 Brain Antibodies  >89 publications with DNMT3A and Brain
 Liver Antibodies  >64 publications with DNMT3A and Liver
 Lung Antibodies  >38 publications with DNMT3A and Lung
 Embryonic Tissue Antibodies  >38 publications with DNMT3A and Embryonic Tissue
 Testis Antibodies  >27 publications with DNMT3A and Testis
 Prostate Antibodies  >25 publications with DNMT3A and Prostate
 Nerve Antibodies  >23 publications with DNMT3A and Nerve
 Muscle Antibodies  >21 publications with DNMT3A and Muscle
 Skin Antibodies  >20 publications with DNMT3A and Skin
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