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anti-DNMT3L antibody :: Rabbit anti-Human DNMT3L Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051534
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNMT3L, Polyclonal Antibody

★Popular Item★
 Also Known As   

DNMT3L Antibody

 Product Synonym Names    DNA (cytosine-5)-methyltransferase 3-like; DNMT3L
 Product Gene Name   

anti-DNMT3L antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF194032 mRNA
 3D Structure    ModBase 3D Structure for Q9UJW3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human DNA (cytosine-5)-methyltransferase 3-like protein (1-234AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10239 / sc-10241 / sc-20705
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DNMT3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DNMT3L antibody

   Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
 Applications Tested/Suitable for anti-DNMT3L antibody   

ELISA (EIA), Immunofluorescence (IF)

 Application Notes for anti-DNMT3L antibody    IF: 1: 50-1: 200
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 Immunofluorescence (IF) of anti-DNMT3L antibody    Immunofluorescent analysis of Hela cells using MBS7051534 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DNMT3L antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-DNMT3L antibody    Western Blot
Positive WB detected in: PC3 whole cell lysate,HepG2 whole cell lysate,A549 whole cell lysate
All lanes: DNMT3L antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44 KDa
Observed band size: 44 KDa

anti-DNMT3L antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DNMT3L. It may not necessarily be applicable to this product.
 NCBI GI #    28872778
 NCBI GeneID    29947
 NCBI Accession #    NP_037501.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_013369.3 [Other Products]
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 UniProt Primary Accession #    Q9UJW3 [Other Products]
 UniProt Secondary Accession #    Q9BUJ4; E9PB42 [Other Products]
 UniProt Related Accession #    Q9UJW3 [Other Products]
 Molecular Weight    43,670 Da
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 NCBI Official Full Name    DNA (cytosine-5)-methyltransferase 3-like isoform 1
 NCBI Official Synonym Full Names    DNA methyltransferase 3 like
 NCBI Official Symbol    DNMT3L [Similar Products]
 NCBI Protein Information    DNA (cytosine-5)-methyltransferase 3-like
 UniProt Protein Name    DNA (cytosine-5)-methyltransferase 3-like
 Protein Family    DNA (cytosine-5)-methyltransferase
 UniProt Gene Name    DNMT3L [Similar Products]
 UniProt Entry Name    DNM3L_HUMAN
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 NCBI Summary for DNMT3L    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for DNMT3L    Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
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 Research Articles on DNMT3L    1. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNMT3L antibodyPathways associated with anti-DNMT3L antibody
 Reference Product  PubMed Publications
 DNMT3A antibody  >138 publications with DNMT3L and DNMT3A
 DNMT3B antibody  >106 publications with DNMT3L and DNMT3B
 DNMT1 antibody  >62 publications with DNMT3L and DNMT1
 HDAC1 antibody  >7 publications with DNMT3L and HDAC1
 TRDMT1 antibody  >5 publications with DNMT3L and TRDMT1
 TDG antibody  >2 publications with DNMT3L and TDG
 Products by Pathway  Pathway Diagram
 DNA Methylation Pathway antibodies  DNA Methylation Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Preimplantation Embryo Pathway antibodies  Preimplantation Embryo Pathway Diagram
 Trans-sulfuration And One Carbon Metabolism Pathway antibodies  Trans-sulfuration And One Carbon Metabolism Pathway Diagram
Diseases associated with anti-DNMT3L antibodyOrgans/Tissues associated with anti-DNMT3L antibody
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >15 publications with DNMT3L and Infertility, Male
 Congenital Abnormalities Antibodies  >9 publications with DNMT3L and Congenital Abnormalities
 Infertility, Female Antibodies  >6 publications with DNMT3L and Infertility, Female
 Cell Transformation, Neoplastic Antibodies  >4 publications with DNMT3L and Cell Transformation, Neoplastic
 Prenatal Exposure Delayed Effects Antibodies  >4 publications with DNMT3L and Prenatal Exposure Delayed Effects
 Oligospermia Antibodies  >3 publications with DNMT3L and Oligospermia
 Liver Neoplasms Antibodies  >2 publications with DNMT3L and Liver Neoplasms
 Inflammation Antibodies  >2 publications with DNMT3L and Inflammation
 Liver Diseases Antibodies  >2 publications with DNMT3L and Liver Diseases
 Growth Disorders Antibodies  >2 publications with DNMT3L and Growth Disorders
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >31 publications with DNMT3L and Testis
 Embryonic Tissue Antibodies  >21 publications with DNMT3L and Embryonic Tissue
 Placenta Antibodies  >11 publications with DNMT3L and Placenta
 Mixed Antibodies  >3 publications with DNMT3L and Mixed
 Epididymis Antibodies  >1 publications with DNMT3L and Epididymis
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