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anti-DPP4 antibody :: Rabbit DPP4 / CD26 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240136
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DPP4 / CD26, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human DPP4 / CD26

 Product Synonym Names    Anti-DPP4 / CD26 Antibody (N-Terminus) IHC-plus; DPP4; ADCP-2; ADABP; Dipeptidyl peptidase IV; Dipeptidyl-peptidase 4; DPPIV; ADCP2; T-cell activation antigen CD26; CD26; CD26 antigen; Dipeptidyl peptidase 4; Dipeptidylpeptidase 4; DPP IV; TP103; Human DPP4; CD26
 Product Gene Name   

anti-DPP4 antibody

[Similar Products]
 Product Synonym Gene Name    CD26 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102720
 3D Structure    ModBase 3D Structure for P27487
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Human, Orangutan
Predicted Reactivity: Gorilla, Monkey, Bovine (at least 90% immunogen sequence identity)
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 Specificity    Human CD26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 15 amino acid peptide from N-terminus of human CD26. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey (100%); Gorilla, Marmoset, Bovine (93%); Cat, Rabbit (87%); Dog, Bat, Elephant, Panda, Horse (80%).
 Immunogen Type    Synthetic peptide
 Immunogen    DPP4 / CD26 antibody was raised against synthetic 15 amino acid peptide from N-terminus of human CD26. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey (100%); Gorilla, Marmoset, Bovine (93%); Cat, Rabbit (87%); Dog, Bat, Elephant, Panda, Horse (80%).
 Antigen Modification    N-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-DPP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DPP4 antibody

   CD26 (DPP4) is is identical to adenosine deaminase complexing protein-2. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
 Product Categories/Family for anti-DPP4 antibody    Family: Protease
Subfamily: Serine S9B
 Applications Tested/Suitable for anti-DPP4 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-DPP4 antibody    IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-DPP4 antibody    Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-DPP4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DPP4. It may not necessarily be applicable to this product.
 NCBI GI #    18765694
 NCBI GeneID    1803
 NCBI Accession #    NP_001926.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001935.3 [Other Products]
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 UniProt Primary Accession #    P27487 [Other Products]
 UniProt Secondary Accession #    Q53TN1 [Other Products]
 UniProt Related Accession #    P27487 [Other Products]
 Molecular Weight    88,279 Da
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 NCBI Official Full Name    dipeptidyl peptidase 4
 NCBI Official Synonym Full Names    dipeptidyl-peptidase 4
 NCBI Official Symbol    DPP4 [Similar Products]
 NCBI Official Synonym Symbols   
CD26; ADABP; ADCP2; DPPIV; TP103
[Similar Products]
 NCBI Protein Information    dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
 UniProt Protein Name    Dipeptidyl peptidase 4
 UniProt Synonym Protein Names   
ADABP; Adenosine deaminase complexing protein 2; ADCP-2; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; TP103; CD_antigen: CD26Cleaved into the following 2 chains:Dipeptidyl peptidase 4 membrane formAlternative name(s):Dipeptidyl peptidase IV membrane form
 Protein Family    Dipeptidyl peptidase
 UniProt Gene Name    DPP4 [Similar Products]
 UniProt Synonym Gene Names    ADCP2; CD26; ADCP-2; DPP IV [Similar Products]
 UniProt Entry Name    DPP4_HUMAN
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 NCBI Summary for DPP4    The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DPP4    DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily.

Protein type: Cell surface; Protease; Membrane protein, integral; Cell adhesion; EC 3.4.14.5

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: intercellular canaliculus; focal adhesion; cell surface; membrane; lamellipodium; lysosomal membrane; endocytic vesicle; apical plasma membrane; integral to membrane; plasma membrane; lipid raft

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; serine-type peptidase activity; dipeptidyl-peptidase activity; serine-type endopeptidase activity; receptor binding

Biological Process: regulation of cell-cell adhesion mediated by integrin; T cell activation; T cell costimulation; positive regulation of cell proliferation; response to hypoxia; endothelial cell migration; proteolysis
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 Research Articles on DPP4    1. DPP4 regulates the expression of the hemoglobin genes, and might play a role in the preservation of renal function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DPP4 antibodyPathways associated with anti-DPP4 antibody
 Reference Product  PubMed Publications
 GIP antibody  >53 publications with DPP4 and GIP
 ADA antibody  >23 publications with DPP4 and ADA
 CXCL12 antibody  >21 publications with DPP4 and CXCL12
 TNF antibody  >10 publications with DPP4 and TNF
 CXCL10 antibody  >6 publications with DPP4 and CXCL10
 GCG antibody  >2 publications with DPP4 and GCG
 CCL11 antibody  >1 publications with DPP4 and CCL11
 Products by Pathway  Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram
Diseases associated with anti-DPP4 antibodyOrgans/Tissues associated with anti-DPP4 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >69 publications with DPP4 and Cardiovascular Diseases
 Inflammation Antibodies  >55 publications with DPP4 and Inflammation
 Disease Models, Animal Antibodies  >51 publications with DPP4 and Disease Models, Animal
 Weight Loss Antibodies  >36 publications with DPP4 and Weight Loss
 Heart Diseases Antibodies  >26 publications with DPP4 and Heart Diseases
 Liver Diseases Antibodies  >26 publications with DPP4 and Liver Diseases
 Hypertension Antibodies  >21 publications with DPP4 and Hypertension
 Kidney Diseases Antibodies  >20 publications with DPP4 and Kidney Diseases
 Adenocarcinoma Antibodies  >17 publications with DPP4 and Adenocarcinoma
 Necrosis Antibodies  >16 publications with DPP4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >333 publications with DPP4 and Blood
 Pancreas Antibodies  >79 publications with DPP4 and Pancreas
 Liver Antibodies  >53 publications with DPP4 and Liver
 Heart Antibodies  >52 publications with DPP4 and Heart
 Vascular Antibodies  >49 publications with DPP4 and Vascular
 Kidney Antibodies  >44 publications with DPP4 and Kidney
 Muscle Antibodies  >30 publications with DPP4 and Muscle
 Intestine Antibodies  >26 publications with DPP4 and Intestine
 Brain Antibodies  >25 publications with DPP4 and Brain
 Lung Antibodies  >25 publications with DPP4 and Lung
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