NP_115963.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,250 Da
NCBI Official Full Name
protein dpy-30 homolog
NCBI Official Synonym Full Names
dpy-30, histone methyltransferase complex regulatory subunit
NCBI Protein Information
protein dpy-30 homolog
UniProt Protein Name
Protein dpy-30 homolog
UniProt Synonym Protein Names
Dpy-30-like protein; Dpy-30L
UniProt Synonym Gene Names
UniProt Entry Name
DPY30_HUMAN
NCBI Summary for DPY30
DPY30 is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]
UniProt Comments for DPY30
DPY30: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family.
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: chromosome, telomeric region; Golgi apparatus; histone methyltransferase complex; nucleoplasm; nucleus; trans-Golgi network
Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); identical protein binding; protein binding; protein homodimerization activity
Biological Process: chromatin silencing at telomere; endosome transport; establishment and/or maintenance of chromatin architecture; histone H3-K4 methylation; transcription, DNA-dependent
Research Articles on DPY30
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Products associated with anti-DPY30 antibody
Pathways associated with anti-DPY30 antibody
Diseases associated with anti-DPY30 antibody
Organs/Tissues associated with anti-DPY30 antibody
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