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anti-DRD5 antibody :: Rabbit anti-Human, mouse DRD5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004556
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DRD5, Polyclonal Antibody

★Popular Item★
 Also Known As   

DRD5 Antibody

 Product Synonym Names    D(1B) dopamine receptor; D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor; DRD5; DRD1B; DRD1L2
 Product Gene Name   

anti-DRD5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126453
 3D Structure    ModBase 3D Structure for P21918
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human D(1B) dopamine receptor protein(361-477AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1440 / sc-25650
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DRD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DRD5 antibody

   Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
 Applications Tested/Suitable for anti-DRD5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-DRD5 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-DRD5 antibody    Western blot
All lanes: DRD5 antibody at 2ug/ml+mouse brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 53kDa
Observed band size: 53kDa

anti-DRD5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-DRD5 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7004556 at dilution 1:100
anti-DRD5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DRD5 antibody    Immunohistochemistry of paraffin-embedded human lung cancer tissue using MBS7004556 at dilution 1:100
anti-DRD5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-DRD5 antibody    Immunofluorescent analysis of U87 cells using MBS7004556 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DRD5 antibody Immunofluorescence (IF) image
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 Immunofluorescence (IF) of anti-DRD5 antibody    Immunofluorescent analysis of A549 cells using MBS7004556 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-DRD5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for DRD5. It may not necessarily be applicable to this product.
 NCBI GI #    4503391
 NCBI GeneID    1816
 NCBI Accession #    NP_000789.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000798.4 [Other Products]
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 UniProt Primary Accession #    P21918 [Other Products]
 UniProt Secondary Accession #    Q8NEQ8; B2R9S3 [Other Products]
 UniProt Related Accession #    P21918 [Other Products]
 Molecular Weight    52,951 Da
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 NCBI Official Full Name    D(1B) dopamine receptor
 NCBI Official Synonym Full Names    dopamine receptor D5
 NCBI Official Symbol    DRD5 [Similar Products]
 NCBI Official Synonym Symbols   
DBDR; DRD1B; DRD1L2
[Similar Products]
 NCBI Protein Information    D(1B) dopamine receptor
 UniProt Protein Name    D(1B) dopamine receptor
 UniProt Synonym Protein Names   
D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor
 Protein Family    D(1B) dopamine receptor
 UniProt Gene Name    DRD5 [Similar Products]
 UniProt Synonym Gene Names    DRD1B; DRD1L2 [Similar Products]
 UniProt Entry Name    DRD5_HUMAN
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 NCBI Summary for DRD5    This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DRD5    DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: brush border membrane; integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity

Biological Process: adenylate cyclase activation; associative learning; cellular calcium ion homeostasis; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; G-protein signaling, adenylate cyclase activating pathway; learning; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of adenylate cyclase activity; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to cocaine; sensitization; synaptic transmission; synaptic transmission, dopaminergic; transmission of nerve impulse; wound healing

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential
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 Research Articles on DRD5    1. This study shown DRD5 to be the risk factor for attention deficit/hyperactivity disorder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DRD5 antibodyDiseases associated with anti-DRD5 antibody
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Disease Name  Pubmed Publications
 Attention Deficit Disorder with Hyperactivity Antibodies  >67 publications with DRD5 and Attention Deficit Disorder with Hyperactivity
 Nervous System Diseases Antibodies  >41 publications with DRD5 and Nervous System Diseases
 Bipolar Disorder Antibodies  >11 publications with DRD5 and Bipolar Disorder
 Hypertension Antibodies  >9 publications with DRD5 and Hypertension
 Disease Models, Animal Antibodies  >8 publications with DRD5 and Disease Models, Animal
 Psychotic Disorders Antibodies  >7 publications with DRD5 and Psychotic Disorders
 Memory Disorders Antibodies  >5 publications with DRD5 and Memory Disorders
 Cardiovascular Diseases Antibodies  >4 publications with DRD5 and Cardiovascular Diseases
 Seizures Antibodies  >3 publications with DRD5 and Seizures
 Blepharospasm Antibodies  >3 publications with DRD5 and Blepharospasm
Organs/Tissues associated with anti-DRD5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >105 publications with DRD5 and Brain
 Eye Antibodies  >4 publications with DRD5 and Eye
 Ovary Antibodies  >2 publications with DRD5 and Ovary
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