NP_004940.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
93,769 Da
NCBI Official Full Name
desmocollin-2 isoform Dsc2b preproprotein
NCBI Official Synonym Full Names
desmocollin 2
NCBI Official Synonym Symbols
DG2; DSC3; CDHF2; ARVD11; DGII/III [Similar Products]
NCBI Protein Information
desmocollin-2
UniProt Protein Name
Desmocollin-2
UniProt Synonym Protein Names
Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III
UniProt Synonym Gene Names
UniProt Entry Name
DSC2_HUMAN
NCBI Summary for DSC2
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for DSC2
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Research Articles on DSC2
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Pathways associated with anti-DSC2 antibody
Diseases associated with anti-DSC2 antibody
Organs/Tissues associated with anti-DSC2 antibody
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